Changes in Tear Lipid Layer Thickness and Symptoms Following the Use of Artificial Tears with and Without Omega-3 Fatty Acids: A Randomized, Double-Masked, Crossover Study

To determine if an eye drop containing omega-3 fatty acids (Refresh Optive MEGA-3 , Allergan plc, Dublin, Ireland) increases the lipid layer thickness (LLT) of the tear film versus a non-emollient eye drop (Refresh Optive, Allergan plc). Patients (≥30 years) with baseline LLT ≤75 nm completed the Cu...

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Bibliographic Details
Published in:Clinical ophthalmology (Auckland, N.Z.) N.Z.), 2019-01, Vol.13, p.2553-2561
Main Authors: Fogt, Jennifer S, Fogt, Nick, King-Smith, P Ewen, Liu, Haixia, Barr, Joseph T
Format: Article
Language:English
Subjects:
Analysis
Clinical Trial Report
Computers
Dermatologic agents
Eye manifestations
Fatty acids
Lipids
Medical research
Omega-3 fatty acids
Ophthalmic agents
Patients
Pharmaceutical industry
Software
Studies
Surveys
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Summary:To determine if an eye drop containing omega-3 fatty acids (Refresh Optive MEGA-3 , Allergan plc, Dublin, Ireland) increases the lipid layer thickness (LLT) of the tear film versus a non-emollient eye drop (Refresh Optive, Allergan plc). Patients (≥30 years) with baseline LLT ≤75 nm completed the Current Symptoms Survey (CSS - a visual analog survey of dry eye symptoms), and LLT was measured pre- and post-instillation (15 and 60 mins) of their randomly assigned treatment. After washout, patients were tested with the other treatment. Primary endpoint: change in LLT from baseline. Secondary endpoint: CSS results. Of 21 patients enrolled, 19 completed the study. With the omega-3-containing eye drop, the mean (standard deviation) LLT increase from baseline at 15 mins was statistically significant in the overall field (8.8 [11.5] nm;
ISSN:1177-5467
1177-5483
1177-5483
DOI:10.2147/OPTH.S228261