No metagenomic evidence of tumorigenic viruses in cancers from a selected cohort of immunosuppressed subjects

The possible existence of yet undiscovered human tumorigenic viruses is still under scrutiny. The development of large-scale sequencing technologies, coupled with bioinformatics techniques for the characterization of metagenomic sequences, have provided an invaluable tool for the detection of unknow...

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Bibliographic Details
Published in:Scientific reports 2019-12, Vol.9 (1), p.19815-8, Article 19815
Main Authors: Passaro, Nunzia, Casagrande, Andrea, Chiara, Matteo, Fosso, Bruno, Manzari, Caterina, D’Erchia, Anna Maria, Iesari, Samuele, Pisani, Francesco, Famulari, Antonio, Tulissi, Patrizia, Mastrosimone, Stefania, Maresca, Maria Cristina, Mercante, Giuseppe, Spriano, Giuseppe, Corrado, Giacomo, Vizza, Enrico, Garbuglia, Anna Rosa, Capobianchi, Maria Rosaria, Mottini, Carla, Cenci, Alessandra, Tartaglia, Marco, Costa, Alessandro Nanni, Pesole, Graziano, Crescenzi, Marco
Format: Article
Language:English
Subjects:
45/22
45/23
45/90
631/67/1858
631/67/69
Bioinformatics
Computational Biology - methods
Humanities and Social Sciences
Humans
Immunocompromised Host
Immunosuppression - adverse effects
Metagenome
Metagenomics - methods
Microbiomes
Microbiota
multidisciplinary
Neoplasms - virology
Oncogenic Viruses - genetics
Probability
Science
Science (multidisciplinary)
Sequence Analysis, RNA
Tumorigenesis
Viruses
Viruses - genetics
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Summary:The possible existence of yet undiscovered human tumorigenic viruses is still under scrutiny. The development of large-scale sequencing technologies, coupled with bioinformatics techniques for the characterization of metagenomic sequences, have provided an invaluable tool for the detection of unknown, infectious, tumorigenic agents, as demonstrated by several recent studies. However, discoveries of novel viruses possibly associated with tumorigenesis are scarce at best. Here, we apply a rigorous bioinformatics workflow to investigate in depth tumor metagenomes from a small but carefully selected cohort of immunosuppressed patients. While a variegated bacterial microbiome was associated with each tumor, no evidence of the presence of putative oncoviruses was found. These results are consistent with the major findings of several recent papers and suggest that new human tumorigenic viruses are not common even in immunosuppressed populations.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-56240-1