Multiple sclerosis relapse risk in the postoperative period: Effects of invasive surgery and anesthesia

Background: Postoperative multiple sclerosis (MS) relapses are a concern among patients and providers. Objective: To determine whether MS relapse risk is higher postoperatively. Methods: Data were extracted from medical records of MS patients undergoing surgery at a tertiary center (2000–2016). Cond...

Full description

Saved in:
Bibliographic Details
Published in:Multiple sclerosis 2020-10, Vol.26 (11), p.1437-1440
Main Authors: De Lott, Lindsey B, Zerafa, Samantha, Shedden, Kerby, Dunietz, Galit Levi, Earley, Michelle, Segal, Benjamin M, Braley, Tiffany J
Format: Article
Language:English
Subjects:
Anesthesia
Medical records
Multiple sclerosis
Patients
Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Postoperative multiple sclerosis (MS) relapses are a concern among patients and providers. Objective: To determine whether MS relapse risk is higher postoperatively. Methods: Data were extracted from medical records of MS patients undergoing surgery at a tertiary center (2000–2016). Conditional logistic regression estimated within-patient unadjusted and age-adjusted odds of postoperative versus preoperative relapse. Results: Among 281 patients and 609 surgeries, 12 postoperative relapses were identified. The odds of postoperative versus preoperative relapse in unadjusted (odds ratio (OR) = 0.56, 95% confidence interval (CI) = 0.18–1.79; p = 0.33) or age-adjusted models (OR = 0.66, 95% CI = 0.20–2.16; p = 0.49) were not increased. Conclusions: Surgery/anesthesia exposure did not increase postoperative relapse risk. These findings require confirmation in larger studies.
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458519860304