CEA as a risk factor in predicting ocular metastasis from colorectal cancer

Colorectal, closely following pulmonary and breast, is the third predilection site of cancer that lead to death all over the world. Ocular metastasis (OM) of colorectal cancer (CRC) is becoming increasingly common and presents a poor prognosis. In this study, we detected some recognized tumor biomar...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Cancer 2020, Vol.11 (1), p.51-56
Main Authors: Min, You-Lan, Gong, Ying-Xin, Zhu, Pei-Wen, Lin, Qi, Li, Biao, Shi, Wen-Qing, Yuan, Qing, Shao, Yi
Format: Article
Language:English
Subjects:
Biomarkers
Colorectal cancer
Gender
Metastasis
Patients
Research Paper
Risk factors
Software
Statistical analysis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Colorectal, closely following pulmonary and breast, is the third predilection site of cancer that lead to death all over the world. Ocular metastasis (OM) of colorectal cancer (CRC) is becoming increasingly common and presents a poor prognosis. In this study, we detected some recognized tumor biomarkers and tried to differentiate the discrepancy between CRC patients with and without OM in order to clarify the risk factor for OM in patients with colorectal cancer. 1735 patients with colorectal cancer in total from August 2005 to August 2017 were involved in this study. Nonparametric rank sum test and Chi-square test were applied to prescribe whether there were significant differences between OM group and non-ocular metastasis (NOM) group. And binary logistic regression analysis was used to determine the risk factor. Then, we used receiver operating curve (ROC) to assess the diagnostic value of OM in CRC patients. The incidence of OM in CRC patients was 1.12%. No significant differences were found in gender, age, histopathological type, tumor classification and tumor differentiation between OM group and NOM group. Nonparametric rank sum test approved that OM group had higher serum CEA level compared with NOM group. Binary logistic regression indicated that CEA was a risk factor for OM in colorectal cancer patients (p
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.31196