Loading…
Phytochemical Composition and Bioactive Effects of Salvia africana , Salvia officinalis 'Icterina' and Salvia mexicana Aqueous Extracts
In the present study, aqueous extracts of , and origin were screened for their phenolic composition and for antibacterial, antioxidant, anti-inflammatory and cytotoxic properties. The three aqueous extracts contained distinct phenolic compounds, with presenting the highest total levels (231.6 ± 7.5...
Saved in:
Published in: | Molecules (Basel, Switzerland) Switzerland), 2019-11, Vol.24 (23), p.4327 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | In the present study, aqueous extracts of
,
and
origin were screened for their phenolic composition and for antibacterial, antioxidant, anti-inflammatory and cytotoxic properties. The three aqueous extracts contained distinct phenolic compounds, with
presenting the highest total levels (231.6 ± 7.5 μg/mg). Rosmarinic acid was the dominant phenolic compound in all extracts, yet that of
origin was characterized by the present of yunnaneic acid isomers, which overall accounted for about 40% of total phenolics. In turn,
extract presented glycosidic forms of apigenin, luteolin and scuttelarein, and the one obtained from
contained several simple caffeic acid derivatives.
aqueous extract exhibited high antioxidant potential in four methods, namely the DPPH
(2,2-diphenyl-1-picrylhydrazyl) scavenging ability, iron-reducing power, inhibition of β-carotene bleaching and of thiobarbituric acid reactive substances (TBARS), for which EC
values were equal or only 1.3-3.1 higher than those of the standard compounds. Moreover, this extract was able to lower the levels of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages (EC
= 47.8 ± 2.1 μg/mL). In addition, the three sage aqueous extracts showed promising cytotoxic effect towards hepatocellular HepG2, cervical HeLa, and breast carcinoma cells MCF-7. Overall this study highlights the potential of three little-exploited
species, with commercial value for applications in food or pharmaceutical industries. |
---|---|
ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules24234327 |