Effects of Huazhuo Jiedu Shugan Decoction on Cognitive and Emotional Disorders in a Rat Model of Epilepsy: Possible Involvement of AC-cAMP-CREB Signaling and NPY Expression

Background. Huazhuo Jiedu Shugan decoction (HJSD), a traditional Chinese medicine (TCM), has been used to treat epileptic seizures for many years. Some ingredients in these herbs have been demonstrated to be effective for the treatment of brain damage caused by epilepsy. Aim of the Study. The object...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2019, Vol.2019 (2019), p.1-15
Main Authors: Pei, Lin, Chu, Li, Zhang, Yan-Hong, Cao, Ya-Fei, Zhao, Ya-Nan, Lu, Ye, Liu, Shu-Ning, Qin, Shao-Kun, Ping, Xin, Zhang, Shao-Dan
Format: Article
Language:English
Subjects:
Adenylate cyclase
AMP
Animal behavior
Behavior
Brain damage
Brain injury
Chinese medicine
Cognitive ability
Convulsions
Convulsions & seizures
Cyclic adenylic acid
Cyclic AMP response element-binding protein
Drug dosages
Emotional disorders
Emotions
Epilepsy
Experiments
Group dynamics
Herbal medicine
Herbs
Hippocampus
Laboratory animals
Latency
Medical research
Medicinal plants
Medicine, Botanic
Medicine, Chinese
Medicine, Herbal
Mental illness
Neuropeptide Y
Polyclonal antibodies
Protein binding
Quality of life
Rodents
Seizures
Seizures (Medicine)
Traditional Chinese medicine
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Summary:Background. Huazhuo Jiedu Shugan decoction (HJSD), a traditional Chinese medicine (TCM), has been used to treat epileptic seizures for many years. Some ingredients in these herbs have been demonstrated to be effective for the treatment of brain damage caused by epilepsy. Aim of the Study. The object of the study is to determine the effects of HJSD on cognitive and emotional disorders in a rat model of epilepsy. Materials and Methods. After a predetermined time period, rats were intraperitoneally injected with pentylenetetrazol and observed in different phases of convulsions. The cognitive and emotional changes in the epileptic rats were assessed using behavioral and immunohistochemical tests. Results. Compared with the epilepsy group, the seizure grade was reduced and seizure latency was prolonged following HJSD-H treatment (P
ISSN:1741-427X
1741-4288
DOI:10.1155/2019/4352879