Evaluation of Tp-E Interval and Tp-E/QT Ratio in Patients with Aortic Stenosis

• Published in: Annals of noninvasive electrocardiology 2016-05, Vol.21 (3), p.287-293
• Main Authors: Yayla, Çağrı, Bilgin, Murat, Akboğa, Mehmet Kadri, Gayretli Yayla, Kadriye, Canpolat, Uğur, Dinç Asarcikli, Lale, Doğan, Mehmet, Turak, Osman, Çay, Serkan, Özeke, Özcan, Akyel, Ahmet, Yeter, Ekrem, Aydoğdu, Sinan
• Format: Article
• Language: English
• Subjects: Aged; aortic stenosis; Aortic Valve Stenosis - physiopathology; Arrhythmias, Cardiac - physiopathology; Cardiac arrhythmia; Case-Control Studies; Death, Sudden, Cardiac; Echocardiography; Electrocardiography; Female; Heart Conduction System - physiopathology; Humans; Male; Middle Aged; Original; Ratios; Risk Factors; Severity of Illness Index; Syncope - physiopathology; Tp-e interval; Tp-e/QT ratio
• ISSN: 1082-720X; 1542-474X
• DOI: 10.1111/anec.12298

Background The risk of syncope and sudden cardiac death due to ventricular arrhythmias increased in patients with aortic stenosis (AS). Recently, it was shown that Tp‐e interval, Tp‐e/QT, and Tp‐e/QTc ratio can be novel indicators for prediction of ventricular arrhythmias and mortality. We aimed to investigate the association between AS and ventricular repolarization using Tp‐e interval and Tp‐e/QT ratio. Methods Totally, 105 patients with AS and 60 control subjects were enrolled to this study. The severity of AS was defined by transthoracic echocardiographic examination. Tp‐e interval, Tp‐e/QT, and Tp‐e/QTc ratios were measured from the 12‐lead electrocardiogram. Results Tp‐e interval, Tp‐e/QT, and Tp‐e/QTc ratios were significantly increased in parallel to the severity of AS (P < 0.001, P = 0.001, and P = 0.001, respectively). Also, it was shown that Tp‐e/QTc ratio had significant positive correlation with mean aortic gradient (r = 0.192, P = 0.049). In multivariate logistic regression analysis, Tp‐e/QTc ratio and left ventricular mass were found to be independent predictors of severe AS (P = 0.03 and P = 0.04, respectively). Conclusions Our study showed that Tp‐e interval, Tp‐e/QT, and Tp‐e/QTc ratios were increased in patients with severe AS. Tp‐e/QTc ratio and left ventricular mass were found as independent predictors of severe AS.