circFBXL5 promotes breast cancer progression by sponging miR‐660

Increasing studies have revealed that circular RNAs (circRNAs) play important roles in cancer progression. However, the potential involvement of circRNAs in breast cancer metastasis to lung is not clear so far. In this study, we conducted circular RNA microarrays of primary breast cancer tissues and...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2020-01, Vol.24 (1), p.356-361
Main Authors: Zhou, Huamao, Tang, Guohui, Zhao, Mi, Xie, Liming, Xie, Yuanjie, Zhang, Zhiwei, He, Xiusheng
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Binding sites
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cell adhesion & migration
Cell cycle
Cell growth
Cell migration
Cell Movement - genetics
Cell proliferation
Cell Proliferation - genetics
Circular RNA
circular RNAs
Cluster analysis
competitive endogenous RNAs
Disease Progression
DNA microarrays
Female
Gene Expression Regulation, Neoplastic
Humans
Lung cancer
Metastases
Metastasis
Mice, Inbred BALB C
Mice, Nude
MicroRNAs - genetics
MicroRNAs - metabolism
Original
Phosphoproteins - genetics
Phosphoproteins - metabolism
RNA, Circular - genetics
RNA, Circular - metabolism
Serine-Arginine Splicing Factors - genetics
Serine-Arginine Splicing Factors - metabolism
Statistical analysis
Survival analysis
Therapeutic applications
Therapeutic targets
Tissue analysis
Tissues
Treatment Outcome
Tumors
Up-Regulation - genetics
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Description
Summary:Increasing studies have revealed that circular RNAs (circRNAs) play important roles in cancer progression. However, the potential involvement of circRNAs in breast cancer metastasis to lung is not clear so far. In this study, we conducted circular RNA microarrays of primary breast cancer tissues and lung metastatic tissues. The results revealed that circFBXL5 (hsa_circ_0125597) up‐regulated the most in lung metastatic tissues. Survival analysis revealed that high levels of circFBXL5 correlated with worse outcome of breast cancer. Further experiments showed that knockdown of circFBXL5 inhibited breast cancer cell proliferation and migration to lung. Mechanism study showed that circFBXL5 acted as a sponge for miR‐660 and compete binding to miR‐660 with SRSF6, leading to increased expression of SRSF6. Collectively, our study highlighted the regulatory function of the circFBXL5/miR‐660/SRSF6 pathway in breast cancer progression, which could be potential therapeutic targets for breast cancer.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.14737