Not all proteinuria is created equal

Albuminuria acts as a marker of progressive chronic kidney disease and as an indicator for initiation of hypertension treatment via modulation of the renin-angiotensin-aldosterone system with angiotensin receptor blockers or angiotensin-converting enzyme inhibitors. However, the true significance of...

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Bibliographic Details
Published in:The Journal of clinical investigation 2020-01, Vol.130 (1), p.74-76
Main Authors: Beenken, Andrew, Barasch, Jonathan M, Gharavi, Ali G
Format: Article
Language:English
Subjects:
Albuminuria
Aldosterone
Angiotensin-Converting Enzyme Inhibitors
Angiotensins
Chronic kidney failure
Development and progression
Diseases
Enzyme inhibitors
Enzymes
Genes
Glucocorticoids
Humans
Hypertension
Kidney diseases
Proteinuria
Renal Insufficiency, Chronic
Renin-Angiotensin System
Type 2 diabetes
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Summary:Albuminuria acts as a marker of progressive chronic kidney disease and as an indicator for initiation of hypertension treatment via modulation of the renin-angiotensin-aldosterone system with angiotensin receptor blockers or angiotensin-converting enzyme inhibitors. However, the true significance of albuminuria has yet to be fully defined. Is it merely a marker of underlying pathophysiology, or does it play a causal role in the progression of kidney disease? The answer remains under debate. In this issue of the JCI, Bedin et al. used next-generation sequencing data to identify patients with chronic proteinuria who had biallelic variants in the cubilin gene (CUBN). Through investigation of these pathogenic mutations in CUBN, the authors have further illuminated the clinical implications of albuminuria.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI133250