Regulation of miRNAs as new tool for cutaneous vitality lesions demonstration in ligature marks in deaths by hanging

This study aims to demonstrate that the application of miRNA expression in forensic pathology, in cases of hanging, applying the method on skin samples. The proposed investigative protocol allowed us to highlight a different miRNA expression in the skin ligature marks of subjects who died by hanging...

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Bibliographic Details
Published in:Scientific reports 2019-12, Vol.9 (1), p.20011-10, Article 20011
Main Authors: Neri, Margherita, Fabbri, Matteo, D’Errico, Stefano, Di Paolo, Marco, Frati, Paola, Gaudio, Rosa Maria, La Russa, Raffaele, Maiese, Aniello, Marti, Matteo, Pinchi, Enrica, Turillazzi, Emanuela, Fineschi, Vittorio
Format: Article
Language:English
Subjects:
13/105
13/51
13/89
45/61
692/308/2056
692/53/2421
Adult
Anti-inflammatory agents
Asphyxia
Cause of Death
Cell activation
Female
Forensic Medicine
Forensic pathology
Forensic science
Humanities and Social Sciences
Humans
Inflammation
Lesions
Leukocytes (neutrophilic)
Male
MicroRNAs - genetics
miRNA
multidisciplinary
Science
Science (multidisciplinary)
Skin - pathology
Skin diseases
Skin lesions
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Summary:This study aims to demonstrate that the application of miRNA expression in forensic pathology, in cases of hanging, applying the method on skin samples. The proposed investigative protocol allowed us to highlight a different miRNA expression in the skin ligature marks of subjects who died by hanging compared to healthy skin control samples. The results obtained showed an increase in the expression of miRNAs recognized as regulators of the inflammatory response in skin lesions such as miR125a-5p and miR125b-5p. Furthermore, overexpression of additional miRNAs – miR214a-3p, miR128-3p, miR130a-3p, and miR92a-3p – with anti-inflammatory activity was highlighted. It was possible to document a statistical significance to control skin samples only for miR103a-3p (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-56682-7