Therapeutic Effects of Nano-HAp in a Rat Model of AlCl3 Induced Neurotoxicity

• Published in: Iranian journal of pharmaceutical research : IJPR 2019-06, Vol.18 (3), p.1309-1322
• Main Authors: Abbas, Osma Ahmed, Ibrahim, Issa Ghada, Ismail, Abdel-Gawad Eman
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 1735-0328; 1726-6890
• DOI: 10.22037/ijpr.2019.1100760

With the advance in nanomedicine, the present study was conducted to explore the possible therapeutic role of intravenous nano- hydroxyapatite (nano-HAp) in male rats after chronic exposure to aluminum chloride (AlCl3). This exposure interposed DNA fragmentation, apoptosis, alters oxidant/antioxidant status as well as change in content of neurotransmitters. The rats were injected with 100 mg/kg. body weight (b.w.) of AlCl3 intraperitoneally for 90 days, after then nano-HAp was injected intravenously (i.v.) three times per week at a dose level 100 mg/kg b.w. Based on the results obtained, it can be concluded that the treatment with the prepared nano-HAp restrains the damage inflicted on brain modulation by lipid oxidation products and decreased the susceptibility of apoptotic cells death with subsequent repaired the fragmented DNA as well as improved the synthesis of neurotransmitters. The most salient finding of nano-HAp treatment is the disappearance of most pathological changes due to AlCl3 administration.With the advance in nanomedicine, the present study was conducted to explore the possible therapeutic role of intravenous nano- hydroxyapatite (nano-HAp) in male rats after chronic exposure to aluminum chloride (AlCl3). This exposure interposed DNA fragmentation, apoptosis, alters oxidant/antioxidant status as well as change in content of neurotransmitters. The rats were injected with 100 mg/kg. body weight (b.w.) of AlCl3 intraperitoneally for 90 days, after then nano-HAp was injected intravenously (i.v.) three times per week at a dose level 100 mg/kg b.w. Based on the results obtained, it can be concluded that the treatment with the prepared nano-HAp restrains the damage inflicted on brain modulation by lipid oxidation products and decreased the susceptibility of apoptotic cells death with subsequent repaired the fragmented DNA as well as improved the synthesis of neurotransmitters. The most salient finding of nano-HAp treatment is the disappearance of most pathological changes due to AlCl3 administration.