Terahertz Spectroscopy of Tetrameric Peptides

Determining the sequence and structure of peptides is crucial for understanding their structure–property relationships. Among many techniques, structures are typically elucidated using nuclear magnetic resonance spectroscopy and single crystal X-ray diffraction measurements. In this study, we presen...

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Bibliographic Details
Published in:The journal of physical chemistry letters 2019-05, Vol.10 (10), p.2624-2628
Main Authors: Neu, Jens, Stone, Elizabeth A, Spies, Jacob A, Storch, Golo, Hatano, Ayaka S, Mercado, Brandon Q, Miller, Scott J, Schmuttenmaer, Charles A
Format: Article
Language:English
Subjects:
Chemistry
Density Functional Theory
Materials Science
Peptides - chemistry
Physics
Protein Conformation
Science & Technology - Other Topics
Terahertz Spectroscopy
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Summary:Determining the sequence and structure of peptides is crucial for understanding their structure–property relationships. Among many techniques, structures are typically elucidated using nuclear magnetic resonance spectroscopy and single crystal X-ray diffraction measurements. In this study, we present terahertz time-domain spectroscopy (THz-TDS) as a complementary, nondestructive technique that is sensitive to both the primary and secondary structures of tetrapeptides. Using only a few milligrams of peptide, THz-TDS spectra have been measured, some of which have been supported by density functional theory (DFT) calculations, to distinguish six tetrameric peptides with similar primary and secondary structures.
ISSN:1948-7185
1948-7185
DOI:10.1021/acs.jpclett.9b01091