Gestational exposure to the cannabinoid WIN 55,212-2 and its effect on the innate intestinal immune response

• Published in: Scientific reports 2019-12, Vol.9 (1), p.20340-11, Article 20340
• Main Authors: Hernández-Cervantes, Rosalía, Pérez-Torres, Armando, Prospéro-García, Óscar, Morales Montor, Jorge
• Format: Article
• Language: English
• Subjects: 13/31; 13/51; 14; 14/63; 631/250/127/1213; 631/443/376; 64; Animals; Benzoxazines - chemistry; Benzoxazines - pharmacology; Biomarkers; Calcium Channel Blockers - chemistry; Calcium Channel Blockers - pharmacology; Cannabinoids; Cannabis; Duodenum; Female; Humanities and Social Sciences; Immune response; Immune system; Immunity, Innate; Immunohistochemistry; Immunosuppressive agents; Infections; Intestinal parasites; Intestine; Intestines - drug effects; Intestines - immunology; Killer Cells, Natural - immunology; Killer Cells, Natural - metabolism; Leukocytes (eosinophilic); Male; Marijuana; Maternal Exposure; Molecular Structure; Morpholines - chemistry; Morpholines - pharmacology; multidisciplinary; Naphthalenes - chemistry; Naphthalenes - pharmacology; Offspring; Parasites; Pregnancy; Rats; Rodents; Science; Science (multidisciplinary); T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-019-56653-y

The consequences of marijuana consumption during pregnancy and its effects on the function of the immune system have been little studied. Marijuana is one of the most consumed recreational drugs among pregnant women, and it is known that gestational exposure to marijuana can have serious effects on the offspring after birth. In this study, we challenged the immune system of Wistar rats by infecting them with the parasitic nematode Trichinella spiralis . A treatment group of these animals was prenatally exposed to the cannabinoid WIN 55,212-2; a control group was not exposed. At 5 days of infection, the treated animals were less effective in eliminating intestinal parasites; moreover, this effect was correlated with a deficiency in mucus production, lower recruitment of eosinophils in the duodenum, and a reduced percentage of Tγδ and NK cells. In conclusion, the gestational administration of the synthetic cannabinoid WIN 55,212-2 induces lasting changes to the function of the immune system against infection with T. spiralis in male Wistar rats, making them more susceptible to infection.