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Clinical review on triglycerides
Abstract Hypertriglyceridaemia is a common clinical problem. Epidemiologic and genetic studies have established that triglyceride-rich lipoproteins (TRL) and their remnants as important contributors to ASCVD while severe hypertriglyceridaemia raises risk of pancreatitis. While low-density lipoprotei...
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Published in: | European heart journal 2020-01, Vol.41 (1), p.99-109c |
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creator | Laufs, Ulrich Parhofer, Klaus G Ginsberg, Henry N Hegele, Robert A |
description | Abstract
Hypertriglyceridaemia is a common clinical problem. Epidemiologic and genetic studies have established that triglyceride-rich lipoproteins (TRL) and their remnants as important contributors to ASCVD while severe hypertriglyceridaemia raises risk of pancreatitis. While low-density lipoprotein is the primary treatment target for lipid lowering therapy, secondary targets that reflect the contribution of TRL such as apoB and non-HDL-C are recommended in the current guidelines. Reduction of severely elevated triglycerides is important to avert or reduce the risk of pancreatitis. Here we discuss interventions for hypertriglyceridaemia, including diet and lifestyle, established treatments such as fibrates and omega-3 fatty acid preparations and emerging therapies, including various biological agents. |
doi_str_mv | 10.1093/eurheartj/ehz785 |
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Hypertriglyceridaemia is a common clinical problem. Epidemiologic and genetic studies have established that triglyceride-rich lipoproteins (TRL) and their remnants as important contributors to ASCVD while severe hypertriglyceridaemia raises risk of pancreatitis. While low-density lipoprotein is the primary treatment target for lipid lowering therapy, secondary targets that reflect the contribution of TRL such as apoB and non-HDL-C are recommended in the current guidelines. Reduction of severely elevated triglycerides is important to avert or reduce the risk of pancreatitis. Here we discuss interventions for hypertriglyceridaemia, including diet and lifestyle, established treatments such as fibrates and omega-3 fatty acid preparations and emerging therapies, including various biological agents.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehz785</identifier><identifier>PMID: 31764986</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Clinical Review ; Humans ; Hypertriglyceridemia - therapy ; Life Style ; Triglycerides</subject><ispartof>European heart journal, 2020-01, Vol.41 (1), p.99-109c</ispartof><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology. 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-d8b6bd8995633cdf0de64db6cb361cf1ae306bfe0f75b8aeead57c226ce13a4f3</citedby><cites>FETCH-LOGICAL-c498t-d8b6bd8995633cdf0de64db6cb361cf1ae306bfe0f75b8aeead57c226ce13a4f3</cites><orcidid>0000-0003-2620-9323 ; 0000-0001-9873-0412 ; 0000-0003-2861-5325</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31764986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laufs, Ulrich</creatorcontrib><creatorcontrib>Parhofer, Klaus G</creatorcontrib><creatorcontrib>Ginsberg, Henry N</creatorcontrib><creatorcontrib>Hegele, Robert A</creatorcontrib><title>Clinical review on triglycerides</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Abstract
Hypertriglyceridaemia is a common clinical problem. Epidemiologic and genetic studies have established that triglyceride-rich lipoproteins (TRL) and their remnants as important contributors to ASCVD while severe hypertriglyceridaemia raises risk of pancreatitis. While low-density lipoprotein is the primary treatment target for lipid lowering therapy, secondary targets that reflect the contribution of TRL such as apoB and non-HDL-C are recommended in the current guidelines. Reduction of severely elevated triglycerides is important to avert or reduce the risk of pancreatitis. Here we discuss interventions for hypertriglyceridaemia, including diet and lifestyle, established treatments such as fibrates and omega-3 fatty acid preparations and emerging therapies, including various biological agents.</description><subject>Clinical Review</subject><subject>Humans</subject><subject>Hypertriglyceridemia - therapy</subject><subject>Life Style</subject><subject>Triglycerides</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNqFkD1PwzAQhi0EoqWwM6GOSCjUjuOLvSChii-pEgtIbJbjXFpXaVLspKj8eoJSKpiYbrjnnrt7CTln9JpRxSfY-gUa3ywnuPhMpTggQybiOFKQiEMypEyJCEC-DchJCEtKqQQGx2TAWQqJkjAk42npKmdNOfa4cfgxrqtx49283Fr0LsdwSo4KUwY829UReb2_e5k-RrPnh6fp7SyynaiJcplBlkulBHBu84LmCEmegc04MFswg5xCViAtUpFJg2hykdo4BouMm6TgI3LTe9dttsLcYtV4U-q1dyvjt7o2Tv_tVG6h5_VGg-JSSNkJLncCX7-3GBq9csFiWZoK6zbouHtaAaMx7VDao9bXIXgs9msY1d_B6n2wug-2G7n4fd5-4CfJDrjqgbpd_6_7AiBciOM</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Laufs, Ulrich</creator><creator>Parhofer, Klaus G</creator><creator>Ginsberg, Henry N</creator><creator>Hegele, Robert A</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2620-9323</orcidid><orcidid>https://orcid.org/0000-0001-9873-0412</orcidid><orcidid>https://orcid.org/0000-0003-2861-5325</orcidid></search><sort><creationdate>20200101</creationdate><title>Clinical review on triglycerides</title><author>Laufs, Ulrich ; Parhofer, Klaus G ; Ginsberg, Henry N ; Hegele, Robert A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-d8b6bd8995633cdf0de64db6cb361cf1ae306bfe0f75b8aeead57c226ce13a4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Clinical Review</topic><topic>Humans</topic><topic>Hypertriglyceridemia - therapy</topic><topic>Life Style</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laufs, Ulrich</creatorcontrib><creatorcontrib>Parhofer, Klaus G</creatorcontrib><creatorcontrib>Ginsberg, Henry N</creatorcontrib><creatorcontrib>Hegele, Robert A</creatorcontrib><collection>Oxford Open</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laufs, Ulrich</au><au>Parhofer, Klaus G</au><au>Ginsberg, Henry N</au><au>Hegele, Robert A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical review on triglycerides</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>41</volume><issue>1</issue><spage>99</spage><epage>109c</epage><pages>99-109c</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Abstract
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subjects | Clinical Review Humans Hypertriglyceridemia - therapy Life Style Triglycerides |
title | Clinical review on triglycerides |
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