Calcium Signaling in ß-cell Physiology and Pathology: A Revisit

Pancreatic beta (β) cell dysfunction results in compromised insulin release and, thus, failed regulation of blood glucose levels. This forms the backbone of the development of diabetes mellitus (DM), a disease that affects a significant portion of the global adult population. Physiological calcium (...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2019-12, Vol.20 (24), p.6110
Main Authors: Klec, Christiane, Ziomek, Gabriela, Pichler, Martin, Malli, Roland, Graier, Wolfgang F
Format: Article
Language:English
Subjects:
Animals
Beta cells
Blood glucose
Calcium homeostasis
Calcium ions
Calcium Signaling
Calcium signalling
Carbohydrates
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
Endoplasmic Reticulum - metabolism
Glucagon
Glucose
Golgi Apparatus - metabolism
Homeostasis
Hormones
Humans
Insulin
Insulin resistance
Insulin Secretion
Insulin-Secreting Cells - cytology
Insulin-Secreting Cells - metabolism
Metabolism
Mitochondria - metabolism
Pancreas
Physiology
Plasma
Proteins
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pancreatic beta (β) cell dysfunction results in compromised insulin release and, thus, failed regulation of blood glucose levels. This forms the backbone of the development of diabetes mellitus (DM), a disease that affects a significant portion of the global adult population. Physiological calcium (Ca ) signaling has been found to be vital for the proper insulin-releasing function of β-cells. Calcium dysregulation events can have a dramatic effect on the proper functioning of the pancreatic β-cells. The current review discusses the role of calcium signaling in health and disease in pancreatic β-cells and provides an in-depth look into the potential role of alterations in β-cell Ca homeostasis and signaling in the development of diabetes and highlights recent work that introduced the current theories on the connection between calcium and the onset of diabetes.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20246110