Differences in presentation and survival of Asians compared to Caucasians with ovarian cancer: An NRG Oncology/GOG Ancillary study of 7914 patients

• Published in: Gynecologic oncology 2019-08, Vol.154 (2), p.420-425
• Main Authors: Fuh, Katherine C., Java, James J., Chan, John K., Kapp, Daniel S., Monk, Bradley J., Burger, Robert A., Young, Robert C., Alberts, David S., McGuire, William P., Markman, Maurie, Bell, Jeffrey, Ozols, Robert F., Armstrong, Deborah K., Aghajanian, Carol, Bookman, Michael A., Mannel, Robert S.
• Format: Article
• Language: English
• Subjects: Aged; Asian People - statistics & numerical data; Bevacizumab; Body mass index; Carcinoma, Ovarian Epithelial - diagnosis; Carcinoma, Ovarian Epithelial - mortality; Clear cell; Female; Humans; Kaplan-Meier Estimate; Middle Aged; Ovarian Neoplasms - diagnosis; Ovarian Neoplasms - mortality; Pharmacogenomics; Prognosis; Proportional Hazards Models; Prospective Studies; Racial differences; Randomized Controlled Trials as Topic; Survival Analysis; Survival outcomes; White People - statistics & numerical data
• ISSN: 0090-8258; 1095-6859
• DOI: 10.1016/j.ygyno.2019.05.013

To compare patient/tumor characteristics and outcomes of Asians to Caucasian patients with epithelial ovarian cancer. Ancillary data were pooled and analyzed from ten prospective randomized front-line Gynecologic Oncology Group clinical trials from 1996 to 2011. Demographic, clinicopathologic features, disease-specific and all-cause survival were analyzed. Of 7914 patients, 7641 were Caucasian and 273 Asian. When compared to Caucasians, Asians were younger at trial enrollment, had a better performance status, earlier-stage cancers (17.2% vs. 8.1% with stage I; p