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Differences in presentation and survival of Asians compared to Caucasians with ovarian cancer: An NRG Oncology/GOG Ancillary study of 7914 patients
To compare patient/tumor characteristics and outcomes of Asians to Caucasian patients with epithelial ovarian cancer. Ancillary data were pooled and analyzed from ten prospective randomized front-line Gynecologic Oncology Group clinical trials from 1996 to 2011. Demographic, clinicopathologic featur...
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| Published in: | Gynecologic oncology 2019-08, Vol.154 (2), p.420-425 |
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| container_end_page | 425 |
| container_issue | 2 |
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| container_title | Gynecologic oncology |
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| creator | Fuh, Katherine C. Java, James J. Chan, John K. Kapp, Daniel S. Monk, Bradley J. Burger, Robert A. Young, Robert C. Alberts, David S. McGuire, William P. Markman, Maurie Bell, Jeffrey Ozols, Robert F. Armstrong, Deborah K. Aghajanian, Carol Bookman, Michael A. Mannel, Robert S. |
| description | To compare patient/tumor characteristics and outcomes of Asians to Caucasian patients with epithelial ovarian cancer.
Ancillary data were pooled and analyzed from ten prospective randomized front-line Gynecologic Oncology Group clinical trials from 1996 to 2011. Demographic, clinicopathologic features, disease-specific and all-cause survival were analyzed.
Of 7914 patients, 7641 were Caucasian and 273 Asian. When compared to Caucasians, Asians were younger at trial enrollment, had a better performance status, earlier-stage cancers (17.2% vs. 8.1% with stage I; p |
| doi_str_mv | 10.1016/j.ygyno.2019.05.013 |
| format | article |
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Ancillary data were pooled and analyzed from ten prospective randomized front-line Gynecologic Oncology Group clinical trials from 1996 to 2011. Demographic, clinicopathologic features, disease-specific and all-cause survival were analyzed.
Of 7914 patients, 7641 were Caucasian and 273 Asian. When compared to Caucasians, Asians were younger at trial enrollment, had a better performance status, earlier-stage cancers (17.2% vs. 8.1% with stage I; p < 0.001), and were more likely to be of clear cell (15.8% vs. 6.2%, p < 0.001) and mucinous (3.3% vs. 1.9%, p < 0.001) histology. Asians had an improved 5-year disease-specific survival of 54.1% compared to 46.1% for Caucasians, p = 0.001. In multivariate analysis, the Asian race remained a significant prognostic factor for all-cause survival (HR: 0.84; 95% CI: 0.72–0.99; p = 0.04). Other factors predictive of improved survival included younger age, better performance status, optimal cytoreduction, earlier stage, non-clear cell histology, and lower grade tumors.
Asians enrolled into phase III ovarian cancer clinical trials were younger, with better performance status, earlier-stage of disease, and have a greater number of clear cell and mucinous tumors. After adjusting for these prognostic factors, Asians have a better survival compared to Caucasians.
•Asians were younger at trial enrollment and had better performance status.•Asians had improved 5-year disease-specific survival than Caucasians.•Asian race remained significant prognostic factor in multivariate analysis.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1016/j.ygyno.2019.05.013</identifier><identifier>PMID: 31229298</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Asian People - statistics & numerical data ; Bevacizumab ; Body mass index ; Carcinoma, Ovarian Epithelial - diagnosis ; Carcinoma, Ovarian Epithelial - mortality ; Clear cell ; Female ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Ovarian Neoplasms - diagnosis ; Ovarian Neoplasms - mortality ; Pharmacogenomics ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Racial differences ; Randomized Controlled Trials as Topic ; Survival Analysis ; Survival outcomes ; White People - statistics & numerical data</subject><ispartof>Gynecologic oncology, 2019-08, Vol.154 (2), p.420-425</ispartof><rights>2019</rights><rights>Copyright © 2019. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-956de26db817864176ce8892b158e1bb51b0f74f558d814e315a9930734784783</citedby><cites>FETCH-LOGICAL-c459t-956de26db817864176ce8892b158e1bb51b0f74f558d814e315a9930734784783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31229298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuh, Katherine C.</creatorcontrib><creatorcontrib>Java, James J.</creatorcontrib><creatorcontrib>Chan, John K.</creatorcontrib><creatorcontrib>Kapp, Daniel S.</creatorcontrib><creatorcontrib>Monk, Bradley J.</creatorcontrib><creatorcontrib>Burger, Robert A.</creatorcontrib><creatorcontrib>Young, Robert C.</creatorcontrib><creatorcontrib>Alberts, David S.</creatorcontrib><creatorcontrib>McGuire, William P.</creatorcontrib><creatorcontrib>Markman, Maurie</creatorcontrib><creatorcontrib>Bell, Jeffrey</creatorcontrib><creatorcontrib>Ozols, Robert F.</creatorcontrib><creatorcontrib>Armstrong, Deborah K.</creatorcontrib><creatorcontrib>Aghajanian, Carol</creatorcontrib><creatorcontrib>Bookman, Michael A.</creatorcontrib><creatorcontrib>Mannel, Robert S.</creatorcontrib><title>Differences in presentation and survival of Asians compared to Caucasians with ovarian cancer: An NRG Oncology/GOG Ancillary study of 7914 patients</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>To compare patient/tumor characteristics and outcomes of Asians to Caucasian patients with epithelial ovarian cancer.
Ancillary data were pooled and analyzed from ten prospective randomized front-line Gynecologic Oncology Group clinical trials from 1996 to 2011. Demographic, clinicopathologic features, disease-specific and all-cause survival were analyzed.
Of 7914 patients, 7641 were Caucasian and 273 Asian. When compared to Caucasians, Asians were younger at trial enrollment, had a better performance status, earlier-stage cancers (17.2% vs. 8.1% with stage I; p < 0.001), and were more likely to be of clear cell (15.8% vs. 6.2%, p < 0.001) and mucinous (3.3% vs. 1.9%, p < 0.001) histology. Asians had an improved 5-year disease-specific survival of 54.1% compared to 46.1% for Caucasians, p = 0.001. In multivariate analysis, the Asian race remained a significant prognostic factor for all-cause survival (HR: 0.84; 95% CI: 0.72–0.99; p = 0.04). Other factors predictive of improved survival included younger age, better performance status, optimal cytoreduction, earlier stage, non-clear cell histology, and lower grade tumors.
Asians enrolled into phase III ovarian cancer clinical trials were younger, with better performance status, earlier-stage of disease, and have a greater number of clear cell and mucinous tumors. After adjusting for these prognostic factors, Asians have a better survival compared to Caucasians.
•Asians were younger at trial enrollment and had better performance status.•Asians had improved 5-year disease-specific survival than Caucasians.•Asian race remained significant prognostic factor in multivariate analysis.</description><subject>Aged</subject><subject>Asian People - statistics & numerical data</subject><subject>Bevacizumab</subject><subject>Body mass index</subject><subject>Carcinoma, Ovarian Epithelial - diagnosis</subject><subject>Carcinoma, Ovarian Epithelial - mortality</subject><subject>Clear cell</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Middle Aged</subject><subject>Ovarian Neoplasms - diagnosis</subject><subject>Ovarian Neoplasms - mortality</subject><subject>Pharmacogenomics</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Racial differences</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Survival Analysis</subject><subject>Survival outcomes</subject><subject>White People - statistics & numerical data</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kd-K1DAUxoMo7rj6BILk0pt286dpE0FhGN1RWBwQvQ5pks5m6CQ1abv0OXxhMzvrojdCIOTkO993kh8ArzEqMcL11aFc9osPJUFYlIiVCNMnYIWRYEXNmXgKVggJVHDC-AV4kdIBIUQRJs_BBcWECCL4Cvz66LrORuu1TdB5OESbrB_V6IKHyhuYpji7WfUwdHCdnPIJ6nAcVLQGjgFu1KTVuXznxlsYZhXzCWqVHeM7uPbw67ct3Hkd-rBfrra7ba5p1_cqLjCNk1lOzo3AFRxyas5OL8GzTvXJvnrYL8GP60_fN5-Lm932y2Z9U-iKibEQrDaW1KbluOF1hZtaW84FaTHjFrctwy3qmqpjjBuOK0sxU0JQ1NCq4XnRS_Dh7DtM7dEanbOj6uUQ3TEPJ4Ny8t8b727lPsyyFhWuGpwN3j4YxPBzsmmUR5e0zW_zNkxJElLVhLJa0CylZ6mOIaVou8cYjOQJpzzIe5zyhFMiJjPO3PXm7wkfe_7wy4L3Z4HN_zQ7G2XS7gTTuGj1KE1w_w34DY8ss6o</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Fuh, Katherine C.</creator><creator>Java, James J.</creator><creator>Chan, John K.</creator><creator>Kapp, Daniel S.</creator><creator>Monk, Bradley J.</creator><creator>Burger, Robert A.</creator><creator>Young, Robert C.</creator><creator>Alberts, David S.</creator><creator>McGuire, William P.</creator><creator>Markman, Maurie</creator><creator>Bell, Jeffrey</creator><creator>Ozols, Robert F.</creator><creator>Armstrong, Deborah K.</creator><creator>Aghajanian, Carol</creator><creator>Bookman, Michael A.</creator><creator>Mannel, Robert S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190801</creationdate><title>Differences in presentation and survival of Asians compared to Caucasians with ovarian cancer: An NRG Oncology/GOG Ancillary study of 7914 patients</title><author>Fuh, Katherine C. ; Java, James J. ; Chan, John K. ; Kapp, Daniel S. ; Monk, Bradley J. ; Burger, Robert A. ; Young, Robert C. ; Alberts, David S. ; McGuire, William P. ; Markman, Maurie ; Bell, Jeffrey ; Ozols, Robert F. ; Armstrong, Deborah K. ; Aghajanian, Carol ; Bookman, Michael A. ; Mannel, Robert S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-956de26db817864176ce8892b158e1bb51b0f74f558d814e315a9930734784783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Asian People - statistics & numerical data</topic><topic>Bevacizumab</topic><topic>Body mass index</topic><topic>Carcinoma, Ovarian Epithelial - diagnosis</topic><topic>Carcinoma, Ovarian Epithelial - mortality</topic><topic>Clear cell</topic><topic>Female</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Middle Aged</topic><topic>Ovarian Neoplasms - diagnosis</topic><topic>Ovarian Neoplasms - mortality</topic><topic>Pharmacogenomics</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Racial differences</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Survival Analysis</topic><topic>Survival outcomes</topic><topic>White People - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuh, Katherine C.</creatorcontrib><creatorcontrib>Java, James J.</creatorcontrib><creatorcontrib>Chan, John K.</creatorcontrib><creatorcontrib>Kapp, Daniel S.</creatorcontrib><creatorcontrib>Monk, Bradley J.</creatorcontrib><creatorcontrib>Burger, Robert A.</creatorcontrib><creatorcontrib>Young, Robert C.</creatorcontrib><creatorcontrib>Alberts, David S.</creatorcontrib><creatorcontrib>McGuire, William P.</creatorcontrib><creatorcontrib>Markman, Maurie</creatorcontrib><creatorcontrib>Bell, Jeffrey</creatorcontrib><creatorcontrib>Ozols, Robert F.</creatorcontrib><creatorcontrib>Armstrong, Deborah K.</creatorcontrib><creatorcontrib>Aghajanian, Carol</creatorcontrib><creatorcontrib>Bookman, Michael A.</creatorcontrib><creatorcontrib>Mannel, Robert S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuh, Katherine C.</au><au>Java, James J.</au><au>Chan, John K.</au><au>Kapp, Daniel S.</au><au>Monk, Bradley J.</au><au>Burger, Robert A.</au><au>Young, Robert C.</au><au>Alberts, David S.</au><au>McGuire, William P.</au><au>Markman, Maurie</au><au>Bell, Jeffrey</au><au>Ozols, Robert F.</au><au>Armstrong, Deborah K.</au><au>Aghajanian, Carol</au><au>Bookman, Michael A.</au><au>Mannel, Robert S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in presentation and survival of Asians compared to Caucasians with ovarian cancer: An NRG Oncology/GOG Ancillary study of 7914 patients</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>154</volume><issue>2</issue><spage>420</spage><epage>425</epage><pages>420-425</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><abstract>To compare patient/tumor characteristics and outcomes of Asians to Caucasian patients with epithelial ovarian cancer.
Ancillary data were pooled and analyzed from ten prospective randomized front-line Gynecologic Oncology Group clinical trials from 1996 to 2011. Demographic, clinicopathologic features, disease-specific and all-cause survival were analyzed.
Of 7914 patients, 7641 were Caucasian and 273 Asian. When compared to Caucasians, Asians were younger at trial enrollment, had a better performance status, earlier-stage cancers (17.2% vs. 8.1% with stage I; p < 0.001), and were more likely to be of clear cell (15.8% vs. 6.2%, p < 0.001) and mucinous (3.3% vs. 1.9%, p < 0.001) histology. Asians had an improved 5-year disease-specific survival of 54.1% compared to 46.1% for Caucasians, p = 0.001. In multivariate analysis, the Asian race remained a significant prognostic factor for all-cause survival (HR: 0.84; 95% CI: 0.72–0.99; p = 0.04). Other factors predictive of improved survival included younger age, better performance status, optimal cytoreduction, earlier stage, non-clear cell histology, and lower grade tumors.
Asians enrolled into phase III ovarian cancer clinical trials were younger, with better performance status, earlier-stage of disease, and have a greater number of clear cell and mucinous tumors. After adjusting for these prognostic factors, Asians have a better survival compared to Caucasians.
•Asians were younger at trial enrollment and had better performance status.•Asians had improved 5-year disease-specific survival than Caucasians.•Asian race remained significant prognostic factor in multivariate analysis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31229298</pmid><doi>10.1016/j.ygyno.2019.05.013</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0090-8258 |
| ispartof | Gynecologic oncology, 2019-08, Vol.154 (2), p.420-425 |
| issn | 0090-8258 1095-6859 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6941471 |
| source | ScienceDirect Journals |
| subjects | Aged Asian People - statistics & numerical data Bevacizumab Body mass index Carcinoma, Ovarian Epithelial - diagnosis Carcinoma, Ovarian Epithelial - mortality Clear cell Female Humans Kaplan-Meier Estimate Middle Aged Ovarian Neoplasms - diagnosis Ovarian Neoplasms - mortality Pharmacogenomics Prognosis Proportional Hazards Models Prospective Studies Racial differences Randomized Controlled Trials as Topic Survival Analysis Survival outcomes White People - statistics & numerical data |
| title | Differences in presentation and survival of Asians compared to Caucasians with ovarian cancer: An NRG Oncology/GOG Ancillary study of 7914 patients |
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