Significance of Serum p53 Antibody as a Tumor Marker in Colorectal Cancer

Objective. We examined serum anti-p53 antibodies (S-p53Ab) in colorectal cancer. Specifically, we retrospectively investigated the use of S-p53Ab as a prognostic marker after surgery for colorectal cancer. Materials and Methods. The levels of S-p53Ab, carcinoembryonic antigen (CEA), and carbohydrate...

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Bibliographic Details
Published in:Disease markers 2019, Vol.2019 (2019), p.1-6
Main Authors: Ishiyama, Shun, Kojima, Yutaka, Okuzawa, Atsushi, Tomiki, Yuichi, Matsuoka, Joe, Aoki, Jun, Okazawa, Yu, Ichikawa, Ryosuke, Tsukamoto, Ryoichi, Motegi, Shunsuke, Sugimoto, Kiichi, Sakamoto, Kazuhiro, Takahashi, Rina, Takahashi, Makoto
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Antibodies
Antibodies - blood
Antigens
Antigens, Tumor-Associated, Carbohydrate - metabolism
Biomarkers
Biomarkers, Tumor - blood
Biomarkers, Tumor - immunology
Cancer
Carbohydrates
Carcinoembryonic antigen
CEA (Oncology)
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - blood
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Digestive System Surgical Procedures
Female
Gender
Humans
Immunoglobulins
Lymphatic system
Male
Markers
Medical research
Metastasis
Middle Aged
Neoplasm Staging
p53 Protein
Patients
Prognosis
Proteins
Retrospective Studies
Statistical analysis
Surgery
Treatment Outcome
Tumor markers
Tumor proteins
Tumor Suppressor Protein p53 - immunology
Tumors
Viral antibodies
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Summary:Objective. We examined serum anti-p53 antibodies (S-p53Ab) in colorectal cancer. Specifically, we retrospectively investigated the use of S-p53Ab as a prognostic marker after surgery for colorectal cancer. Materials and Methods. The levels of S-p53Ab, carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) were measured in 160 colorectal cancer patients who underwent surgical treatment. The rate of postoperative change (RPC) in the S-p53Ab titer was calculated as [subsequent antibody titer-lowest titer]/lowest titer. Results. A relationship between recurrence and RPC in the S-p53Ab titer was not observed in patients who tested negative for S-p53Ab preoperatively. In addition, no patients, who tested negative for S-p53Ab preoperatively, tested positive for S-p53Ab at the follow-up after surgery. Of the patients who tested positive for S-p53Ab preoperatively, those recurrences had a significantly higher RPC compared with those who did not (p
ISSN:0278-0240
1875-8630
DOI:10.1155/2019/2721876