CancerGeneNet: linking driver genes to cancer hallmarks

Abstract CancerGeneNet (https://signor.uniroma2.it/CancerGeneNet/) is a resource that links genes that are frequently mutated in cancers to cancer phenotypes. The resource takes advantage of a curation effort aimed at embedding a large fraction of the gene products that are found altered in cancer c...

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Bibliographic Details
Published in:Nucleic acids research 2020-01, Vol.48 (D1), p.D416-D421
Main Authors: Iannuccelli, Marta, Micarelli, Elisa, Surdo, Prisca Lo, Palma, Alessandro, Perfetto, Livia, Rozzo, Ilaria, Castagnoli, Luisa, Licata, Luana, Cesareni, Gianni
Format: Article
Language:English
Subjects:
Algorithms
Antineoplastic Agents - pharmacology
Computer Graphics
Database Issue
Databases, Genetic
Humans
Molecular Targeted Therapy
Neoplasms - drug therapy
Neoplasms - genetics
Phenotype
Proteins - genetics
User-Computer Interface
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Summary:Abstract CancerGeneNet (https://signor.uniroma2.it/CancerGeneNet/) is a resource that links genes that are frequently mutated in cancers to cancer phenotypes. The resource takes advantage of a curation effort aimed at embedding a large fraction of the gene products that are found altered in cancer cells into a network of causal protein relationships. Graph algorithms, in turn, allow to infer likely paths of causal interactions linking cancer associated genes to cancer phenotypes thus offering a rational framework for the design of strategies to revert disease phenotypes. CancerGeneNet bridges two interaction layers by connecting proteins whose activities are affected by cancer drivers to proteins that impact on the ‘hallmarks of cancer’. In addition, CancerGeneNet annotates curated pathways that are relevant to rationalize the pathological consequences of cancer driver mutations in selected common cancers and ‘MiniPathways’ illustrating regulatory circuits that are frequently altered in different cancers.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkz871