Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9

• Published in: Molecules (Basel, Switzerland) Switzerland), 2019-12, Vol.24 (24), p.4596
• Main Authors: Liu, Yu-Jing, Zhang, Jian-Long, Li, Chen, Mu, Xue-Gen, Liu, Xiao-Li, Wang, Lei, Zhao, Yan-Cui, Zhang, Peng, Li, Xiao-Dong, Zhang, Xing-Xiao
• Format: Article
• Language: English
• Subjects: Anti-Infective Agents - chemistry; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; Antibiotics; Antimicrobial agents; Aquatic Organisms; Aspergillus - chemistry; Aspergillus - metabolism; Bisabolene; Carbon; Carbon radioisotopes; Chemical analysis; Chloramphenicol; Chloromycetin; Correlation; Fermentation; Fungi; Humans; Magnetic Resonance Spectroscopy; Metabolites; Microbial Sensitivity Tests; Minimum inhibitory concentration; Models, Molecular; Molecular Structure; Morphology; NMR; Nuclear magnetic resonance; Seawater; Seawater - microbiology; Secondary Metabolism; Secondary metabolites; Shikimic acid; Streptococcus infections; Two dimensional analysis; Water analysis; Water Microbiology
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules24244596

Marine-derived fungi are considered to be valuable producers of bioactive secondary metabolites used as lead compounds with medicinal importance. In this study, chemical investigation of the seawater-derived fungus SW9 led to the isolation and identification of one new quinazolinone alkaloid, 2-(4-hydroxybenzyl)-4-(3-acetyl)quinazolin-one ( ), one new aromatic bisabolene-type sesquiterpenoid, ( ) and one new chorismic acid analogue ( ), as well as two known alkaloids (compounds and ). Their structures were determined by extensive 1D/2D NMR and mass spectrometric data, and the absolute configurations of and were assigned by the analysis of ECD spectra aided by quantum chemical computations. Compounds , and exhibited selective inhibitory activities against the human pathogenic bacteria , , and , with MIC values ranging from 2.0 to 16 μg/mL.