Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System

Human prion diseases are neurodegenerative disorders caused by prion protein. Although infectivity was historically detected only in the central nervous system and lymphoreticular tissues of patients with sporadic Creutzfeldt-Jakob disease, recent reports suggest that the seeding activity of Creutzf...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-12, Vol.24 (24), p.4601
Main Authors: Satoh, Katsuya, Fuse, Takayuki, Nonaka, Toshiaki, Dong, Trong, Takao, Masaki, Nakagaki, Takehiro, Ishibashi, Daisuke, Taguchi, Yuzuru, Mihara, Ban, Iwasaki, Yasushi, Yoshida, Mari, Nishida, Noriyuki
Format: Article
Language:English
Subjects:
Adult
Aged
Animal models
Animals
Brain research
Case-Control Studies
Creutzfeldt-Jakob disease
Creutzfeldt-Jakob Syndrome - metabolism
Creutzfeldt-Jakob Syndrome - pathology
Digestive system
Digestive System - metabolism
Digestive System - pathology
Encephalitis
Epithelium
Esophagus
Female
Humans
Immunohistochemistry
Infections
Infectivity
Male
Middle Aged
Olfactory epithelium
Organ Specificity
Ostomy
Patients
Postmortem Changes
Prion Diseases - metabolism
Prion Diseases - pathology
Prion protein
Prions
Prions - metabolism
Protein seeding
Proteins
Quantitative analysis
Reabsorption
Scrapie
Spleen
Stomach
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c537t-128f87099c4617021257b7e05ca62b1bba33754996867b72e91f4a4c5d1a19683
cites cdi_FETCH-LOGICAL-c537t-128f87099c4617021257b7e05ca62b1bba33754996867b72e91f4a4c5d1a19683
container_end_page
container_issue 24
container_start_page 4601
container_title Molecules (Basel, Switzerland)
container_volume 24
creator Satoh, Katsuya
Fuse, Takayuki
Nonaka, Toshiaki
Dong, Trong
Takao, Masaki
Nakagaki, Takehiro
Ishibashi, Daisuke
Taguchi, Yuzuru
Mihara, Ban
Iwasaki, Yasushi
Yoshida, Mari
Nishida, Noriyuki
description Human prion diseases are neurodegenerative disorders caused by prion protein. Although infectivity was historically detected only in the central nervous system and lymphoreticular tissues of patients with sporadic Creutzfeldt-Jakob disease, recent reports suggest that the seeding activity of Creutzfeldt-Jakob disease prions accumulates in various non-neuronal organs including the liver, kidney, and skin. Therefore, we reanalyzed autopsy samples collected from patients with sporadic and genetic human prion diseases and found that seeding activity exists in almost all digestive organs. Unexpectedly, activity in the esophagus reached a level of prion seeding activity close to that in the central nervous system in some CJD patients, indicating that the safety of endoscopic examinations should be reconsidered.
doi_str_mv 10.3390/molecules24244601
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6943689</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2331636943</sourcerecordid><originalsourceid>FETCH-LOGICAL-c537t-128f87099c4617021257b7e05ca62b1bba33754996867b72e91f4a4c5d1a19683</originalsourceid><addsrcrecordid>eNplkVtLAzEQhYMoXqo_wBcJ-OJLNZNkL3kRincQvFSfQzbNtpHdjSZZof_eqLVUfcqQ-c5hZg5C-0COGRPkpHWN0X1jAuWU85zAGtoGTsmQES7WV-ottBPCCyEUOGSbaItBWZYUim30eO9CbJ2PpsUPveqijSrad4NHnWrmwQbsanzvrevw2JiJ7aZ4pBNg4xzbDseZwed2asKXZjwPyWcXbdSqCWZv8Q7Q8-XF09n18Pbu6uZsdDvUGSviEGhZlwURQvMcijQazYqqMCTTKqcVVJVirMi4EHmZpwY1AmquuM4moCB9sgE6_fZ97avWTLTpoleNfPW2VX4unbLyd6ezMzl17zIXnOWlSAZHCwPv3vq0g2xt0KZpVGdcHyRlDHL2SSf08A_64nqfTvRFMc6AkiJR8E1p70Lwpl4OA0R-Jib_JZY0B6tbLBU_EbEPslmT3A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2333431207</pqid></control><display><type>article</type><title>Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System</title><source>PubMed (Medline)</source><source>Publicly Available Content (ProQuest)</source><creator>Satoh, Katsuya ; Fuse, Takayuki ; Nonaka, Toshiaki ; Dong, Trong ; Takao, Masaki ; Nakagaki, Takehiro ; Ishibashi, Daisuke ; Taguchi, Yuzuru ; Mihara, Ban ; Iwasaki, Yasushi ; Yoshida, Mari ; Nishida, Noriyuki</creator><creatorcontrib>Satoh, Katsuya ; Fuse, Takayuki ; Nonaka, Toshiaki ; Dong, Trong ; Takao, Masaki ; Nakagaki, Takehiro ; Ishibashi, Daisuke ; Taguchi, Yuzuru ; Mihara, Ban ; Iwasaki, Yasushi ; Yoshida, Mari ; Nishida, Noriyuki</creatorcontrib><description>Human prion diseases are neurodegenerative disorders caused by prion protein. Although infectivity was historically detected only in the central nervous system and lymphoreticular tissues of patients with sporadic Creutzfeldt-Jakob disease, recent reports suggest that the seeding activity of Creutzfeldt-Jakob disease prions accumulates in various non-neuronal organs including the liver, kidney, and skin. Therefore, we reanalyzed autopsy samples collected from patients with sporadic and genetic human prion diseases and found that seeding activity exists in almost all digestive organs. Unexpectedly, activity in the esophagus reached a level of prion seeding activity close to that in the central nervous system in some CJD patients, indicating that the safety of endoscopic examinations should be reconsidered.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules24244601</identifier><identifier>PMID: 31888217</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Aged ; Animal models ; Animals ; Brain research ; Case-Control Studies ; Creutzfeldt-Jakob disease ; Creutzfeldt-Jakob Syndrome - metabolism ; Creutzfeldt-Jakob Syndrome - pathology ; Digestive system ; Digestive System - metabolism ; Digestive System - pathology ; Encephalitis ; Epithelium ; Esophagus ; Female ; Humans ; Immunohistochemistry ; Infections ; Infectivity ; Male ; Middle Aged ; Olfactory epithelium ; Organ Specificity ; Ostomy ; Patients ; Postmortem Changes ; Prion Diseases - metabolism ; Prion Diseases - pathology ; Prion protein ; Prions ; Prions - metabolism ; Protein seeding ; Proteins ; Quantitative analysis ; Reabsorption ; Scrapie ; Spleen ; Stomach</subject><ispartof>Molecules (Basel, Switzerland), 2019-12, Vol.24 (24), p.4601</ispartof><rights>2019. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-128f87099c4617021257b7e05ca62b1bba33754996867b72e91f4a4c5d1a19683</citedby><cites>FETCH-LOGICAL-c537t-128f87099c4617021257b7e05ca62b1bba33754996867b72e91f4a4c5d1a19683</cites><orcidid>0000-0001-8007-8710 ; 0000-0002-2719-9756</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2333431207/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2333431207?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31888217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Satoh, Katsuya</creatorcontrib><creatorcontrib>Fuse, Takayuki</creatorcontrib><creatorcontrib>Nonaka, Toshiaki</creatorcontrib><creatorcontrib>Dong, Trong</creatorcontrib><creatorcontrib>Takao, Masaki</creatorcontrib><creatorcontrib>Nakagaki, Takehiro</creatorcontrib><creatorcontrib>Ishibashi, Daisuke</creatorcontrib><creatorcontrib>Taguchi, Yuzuru</creatorcontrib><creatorcontrib>Mihara, Ban</creatorcontrib><creatorcontrib>Iwasaki, Yasushi</creatorcontrib><creatorcontrib>Yoshida, Mari</creatorcontrib><creatorcontrib>Nishida, Noriyuki</creatorcontrib><title>Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>Human prion diseases are neurodegenerative disorders caused by prion protein. Although infectivity was historically detected only in the central nervous system and lymphoreticular tissues of patients with sporadic Creutzfeldt-Jakob disease, recent reports suggest that the seeding activity of Creutzfeldt-Jakob disease prions accumulates in various non-neuronal organs including the liver, kidney, and skin. Therefore, we reanalyzed autopsy samples collected from patients with sporadic and genetic human prion diseases and found that seeding activity exists in almost all digestive organs. Unexpectedly, activity in the esophagus reached a level of prion seeding activity close to that in the central nervous system in some CJD patients, indicating that the safety of endoscopic examinations should be reconsidered.</description><subject>Adult</subject><subject>Aged</subject><subject>Animal models</subject><subject>Animals</subject><subject>Brain research</subject><subject>Case-Control Studies</subject><subject>Creutzfeldt-Jakob disease</subject><subject>Creutzfeldt-Jakob Syndrome - metabolism</subject><subject>Creutzfeldt-Jakob Syndrome - pathology</subject><subject>Digestive system</subject><subject>Digestive System - metabolism</subject><subject>Digestive System - pathology</subject><subject>Encephalitis</subject><subject>Epithelium</subject><subject>Esophagus</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Infections</subject><subject>Infectivity</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Olfactory epithelium</subject><subject>Organ Specificity</subject><subject>Ostomy</subject><subject>Patients</subject><subject>Postmortem Changes</subject><subject>Prion Diseases - metabolism</subject><subject>Prion Diseases - pathology</subject><subject>Prion protein</subject><subject>Prions</subject><subject>Prions - metabolism</subject><subject>Protein seeding</subject><subject>Proteins</subject><subject>Quantitative analysis</subject><subject>Reabsorption</subject><subject>Scrapie</subject><subject>Spleen</subject><subject>Stomach</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNplkVtLAzEQhYMoXqo_wBcJ-OJLNZNkL3kRincQvFSfQzbNtpHdjSZZof_eqLVUfcqQ-c5hZg5C-0COGRPkpHWN0X1jAuWU85zAGtoGTsmQES7WV-ottBPCCyEUOGSbaItBWZYUim30eO9CbJ2PpsUPveqijSrad4NHnWrmwQbsanzvrevw2JiJ7aZ4pBNg4xzbDseZwed2asKXZjwPyWcXbdSqCWZv8Q7Q8-XF09n18Pbu6uZsdDvUGSviEGhZlwURQvMcijQazYqqMCTTKqcVVJVirMi4EHmZpwY1AmquuM4moCB9sgE6_fZ97avWTLTpoleNfPW2VX4unbLyd6ezMzl17zIXnOWlSAZHCwPv3vq0g2xt0KZpVGdcHyRlDHL2SSf08A_64nqfTvRFMc6AkiJR8E1p70Lwpl4OA0R-Jib_JZY0B6tbLBU_EbEPslmT3A</recordid><startdate>20191216</startdate><enddate>20191216</enddate><creator>Satoh, Katsuya</creator><creator>Fuse, Takayuki</creator><creator>Nonaka, Toshiaki</creator><creator>Dong, Trong</creator><creator>Takao, Masaki</creator><creator>Nakagaki, Takehiro</creator><creator>Ishibashi, Daisuke</creator><creator>Taguchi, Yuzuru</creator><creator>Mihara, Ban</creator><creator>Iwasaki, Yasushi</creator><creator>Yoshida, Mari</creator><creator>Nishida, Noriyuki</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8007-8710</orcidid><orcidid>https://orcid.org/0000-0002-2719-9756</orcidid></search><sort><creationdate>20191216</creationdate><title>Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System</title><author>Satoh, Katsuya ; Fuse, Takayuki ; Nonaka, Toshiaki ; Dong, Trong ; Takao, Masaki ; Nakagaki, Takehiro ; Ishibashi, Daisuke ; Taguchi, Yuzuru ; Mihara, Ban ; Iwasaki, Yasushi ; Yoshida, Mari ; Nishida, Noriyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-128f87099c4617021257b7e05ca62b1bba33754996867b72e91f4a4c5d1a19683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Animal models</topic><topic>Animals</topic><topic>Brain research</topic><topic>Case-Control Studies</topic><topic>Creutzfeldt-Jakob disease</topic><topic>Creutzfeldt-Jakob Syndrome - metabolism</topic><topic>Creutzfeldt-Jakob Syndrome - pathology</topic><topic>Digestive system</topic><topic>Digestive System - metabolism</topic><topic>Digestive System - pathology</topic><topic>Encephalitis</topic><topic>Epithelium</topic><topic>Esophagus</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Infections</topic><topic>Infectivity</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Olfactory epithelium</topic><topic>Organ Specificity</topic><topic>Ostomy</topic><topic>Patients</topic><topic>Postmortem Changes</topic><topic>Prion Diseases - metabolism</topic><topic>Prion Diseases - pathology</topic><topic>Prion protein</topic><topic>Prions</topic><topic>Prions - metabolism</topic><topic>Protein seeding</topic><topic>Proteins</topic><topic>Quantitative analysis</topic><topic>Reabsorption</topic><topic>Scrapie</topic><topic>Spleen</topic><topic>Stomach</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Satoh, Katsuya</creatorcontrib><creatorcontrib>Fuse, Takayuki</creatorcontrib><creatorcontrib>Nonaka, Toshiaki</creatorcontrib><creatorcontrib>Dong, Trong</creatorcontrib><creatorcontrib>Takao, Masaki</creatorcontrib><creatorcontrib>Nakagaki, Takehiro</creatorcontrib><creatorcontrib>Ishibashi, Daisuke</creatorcontrib><creatorcontrib>Taguchi, Yuzuru</creatorcontrib><creatorcontrib>Mihara, Ban</creatorcontrib><creatorcontrib>Iwasaki, Yasushi</creatorcontrib><creatorcontrib>Yoshida, Mari</creatorcontrib><creatorcontrib>Nishida, Noriyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Satoh, Katsuya</au><au>Fuse, Takayuki</au><au>Nonaka, Toshiaki</au><au>Dong, Trong</au><au>Takao, Masaki</au><au>Nakagaki, Takehiro</au><au>Ishibashi, Daisuke</au><au>Taguchi, Yuzuru</au><au>Mihara, Ban</au><au>Iwasaki, Yasushi</au><au>Yoshida, Mari</au><au>Nishida, Noriyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2019-12-16</date><risdate>2019</risdate><volume>24</volume><issue>24</issue><spage>4601</spage><pages>4601-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>Human prion diseases are neurodegenerative disorders caused by prion protein. Although infectivity was historically detected only in the central nervous system and lymphoreticular tissues of patients with sporadic Creutzfeldt-Jakob disease, recent reports suggest that the seeding activity of Creutzfeldt-Jakob disease prions accumulates in various non-neuronal organs including the liver, kidney, and skin. Therefore, we reanalyzed autopsy samples collected from patients with sporadic and genetic human prion diseases and found that seeding activity exists in almost all digestive organs. Unexpectedly, activity in the esophagus reached a level of prion seeding activity close to that in the central nervous system in some CJD patients, indicating that the safety of endoscopic examinations should be reconsidered.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31888217</pmid><doi>10.3390/molecules24244601</doi><orcidid>https://orcid.org/0000-0001-8007-8710</orcidid><orcidid>https://orcid.org/0000-0002-2719-9756</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1420-3049
ispartof Molecules (Basel, Switzerland), 2019-12, Vol.24 (24), p.4601
issn 1420-3049
1420-3049
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6943689
source PubMed (Medline); Publicly Available Content (ProQuest)
subjects Adult
Aged
Animal models
Animals
Brain research
Case-Control Studies
Creutzfeldt-Jakob disease
Creutzfeldt-Jakob Syndrome - metabolism
Creutzfeldt-Jakob Syndrome - pathology
Digestive system
Digestive System - metabolism
Digestive System - pathology
Encephalitis
Epithelium
Esophagus
Female
Humans
Immunohistochemistry
Infections
Infectivity
Male
Middle Aged
Olfactory epithelium
Organ Specificity
Ostomy
Patients
Postmortem Changes
Prion Diseases - metabolism
Prion Diseases - pathology
Prion protein
Prions
Prions - metabolism
Protein seeding
Proteins
Quantitative analysis
Reabsorption
Scrapie
Spleen
Stomach
title Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T00%3A01%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Postmortem%20Quantitative%20Analysis%20of%20Prion%20Seeding%20Activity%20in%20the%20Digestive%20System&rft.jtitle=Molecules%20(Basel,%20Switzerland)&rft.au=Satoh,%20Katsuya&rft.date=2019-12-16&rft.volume=24&rft.issue=24&rft.spage=4601&rft.pages=4601-&rft.issn=1420-3049&rft.eissn=1420-3049&rft_id=info:doi/10.3390/molecules24244601&rft_dat=%3Cproquest_pubme%3E2331636943%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c537t-128f87099c4617021257b7e05ca62b1bba33754996867b72e91f4a4c5d1a19683%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2333431207&rft_id=info:pmid/31888217&rfr_iscdi=true