Rescue of TCA Cycle Dysfunction for Cancer Therapy

Mitochondrion, a maternally hereditary, subcellular organelle, is the site of the tricarboxylic acid (TCA) cycle, electron transport chain (ETC), and oxidative phosphorylation (OXPHOS)-the basic processes of ATP production. Mitochondrial function plays a pivotal role in the development and pathology...

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Bibliographic Details
Published in:Journal of clinical medicine 2019-12, Vol.8 (12), p.2161
Main Authors: Marquez, Jubert, Flores, Jessa, Kim, Amy Hyein, Nyamaa, Bayalagmaa, Nguyen, Anh Thi Tuyet, Park, Nammi, Han, Jin
Format: Article
Language:English
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Review
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Summary:Mitochondrion, a maternally hereditary, subcellular organelle, is the site of the tricarboxylic acid (TCA) cycle, electron transport chain (ETC), and oxidative phosphorylation (OXPHOS)-the basic processes of ATP production. Mitochondrial function plays a pivotal role in the development and pathology of different cancers. Disruption in its activity, like mutations in its TCA cycle enzymes, leads to physiological imbalances and metabolic shifts of the cell, which contributes to the progression of cancer. In this review, we explored the different significant mutations in the mitochondrial enzymes participating in the TCA cycle and the diseases, especially cancer types, that these malfunctions are closely associated with. In addition, this paper also discussed the different therapeutic approaches which are currently being developed to address these diseases caused by mitochondrial enzyme malfunction.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm8122161