Body composition reference charts for UK infants and children aged 6 weeks to 5 years based on measurement of total body water by isotope dilution

Background Until recently, pediatric body composition reference data were very limited, hindering interpretation of measurements. In the last decade, such data emerged for several techniques for children ≥ 5 years, but equivalent data for younger age groups remain lacking, due to their poor complian...

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Bibliographic Details
Published in:European journal of clinical nutrition 2020-01, Vol.74 (1), p.141-148
Main Authors: Wells, Jonathan C. K., Davies, Peter S. W., Fewtrell, Mary S., Cole, Tim J.
Format: Article
Language:English
Subjects:
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Abnormalities
Adolescent
Age
Age groups
Aged
Anthropometry
Body Composition
Body fat
Body mass index
Body size
Body Water
Breast
Breastfeeding & lactation
Charts
Child
Children
Clinical medicine
Clinical Nutrition
Deposition
Dilution
Electric Impedance
Epidemiology
Fat-free body mass
Female
Humans
Hydration
Indicator Dilution Techniques
Infant
Infants
Internal Medicine
Isotope dilution techniques
Isotopes
Male
Measurement
Medicine
Medicine & Public Health
Metabolic Diseases
Physiological aspects
Public Health
United Kingdom
Water in the body
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Summary:Background Until recently, pediatric body composition reference data were very limited, hindering interpretation of measurements. In the last decade, such data emerged for several techniques for children ≥ 5 years, but equivalent data for younger age groups remain lacking, due to their poor compliance with most techniques. Objectives To provide reference data for use in clinical practice and research from 6 weeks to 5 years, that are based on measurements of total body water (TBW) by isotope dilution. Design The data on anthropometry and TBW were available from studies of 463 infants and children aged 6 weeks to 7 years, conducted between 1988 and 2010. Both breast-fed and formula-fed infants were included. TBW was measured by 2 H- or 18 O-labeled water, and converted to fat-free mass (FFM) using published hydration coefficients. Reference charts and SD scores (SDS) were constructed for FFM, fat mass (FM), FFM index and FM index for each sex, using the lambda-mu-sigma method. Results Both sexes were significantly heavier and longer than UK 1990 reference data ( p  
ISSN:0954-3007
1476-5640
DOI:10.1038/s41430-019-0409-x