Proximity to major roadways and asthma symptoms in the School Inner-City Asthma Study

Traffic proximity has been associated with adverse respiratory health outcomes. Less is known about the combined impact of residential and school exposures on pediatric asthma. We sought to use spatial analysis methodology to analyze residential and school proximity to major roadways and pediatric a...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2020-01, Vol.145 (1), p.119-126.e4
Main Authors: Hauptman, Marissa, Gaffin, Jonathan M., Petty, Carter R., Sheehan, William J., Lai, Peggy S., Coull, Brent, Gold, Diane R., Phipatanakul, Wanda
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Asthma
Asthma - epidemiology
Asthma - etiology
Child
Child, Preschool
Cities
environmental exposure
Environmental Exposure - adverse effects
environmental health disparities
Female
geographic information systems
Humans
Male
Prospective Studies
school
School Inner-City Asthma Study
Schools
spatial analysis
traffic proximity
Vehicle Emissions - toxicity
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Summary:Traffic proximity has been associated with adverse respiratory health outcomes. Less is known about the combined impact of residential and school exposures on pediatric asthma. We sought to use spatial analysis methodology to analyze residential and school proximity to major roadways and pediatric asthma morbidity. The School Inner-City Asthma Study (n = 350) recruited school-aged children with asthma. Each participant's school and home addresses were geocoded, and distances from major roadways were measured to calculate a composite measure accounting for both home and school traffic exposure. Generalized estimating equation models were clustered by subject and adjusted for age, race/ethnicity, sex, income, environmental tobacco smoke, controller medication, upper respiratory tract infections, and seasonality. The majority of participants (62%) attended schools within 100 m from major roadways, and 40% also resided within 100 m of major roadways. In multivariate analyses major roadway proximity was independently associated with increased asthma symptom days. At greater than the threshold of 100 m, children had 29% less odds of a symptom day over the past 2 weeks for each 100-m increase in distance from a major roadway (odds ratio, 0.71; 95% CI, 0.58-0.87; P 
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2019.08.038