Ozone-induced enhancement of airway hyperreactivity in rhesus macaques: effects of anti-oxidant treatment

O 3 -induced airway inflammation and increased airway hyperreactivity, characterized by selective ILC2, CD1c + mDC and Th cell activation in asthmatic rhesus macaques, was inhibited by pre-treatment with a synthetic lignan (LGM2605).

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2019-10, Vol.145 (1), p.312-323
Main Authors: Flayer, Cameron H., Larson, Erik D., Joseph, Anjali, Kao, Sean, Qu, Wenxiu, Van Haren, Austin, Royer, Christopher M., Miller, Lisa A., Capitanio, John P., Sielecki, Thais, Christofidou-Solomidou, Melpo, Haczku, Angela
Format: Article
Language:English
Online Access:Get full text
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Description
Summary:O 3 -induced airway inflammation and increased airway hyperreactivity, characterized by selective ILC2, CD1c + mDC and Th cell activation in asthmatic rhesus macaques, was inhibited by pre-treatment with a synthetic lignan (LGM2605).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2019.08.034