Irreversible Vasculopathy Proceeds Rapidly in POEMS Syndrome

A 48-year-old woman with polyneuropathy, organomegaly, endocrinopathy, M-protein, skin change (POEMS) syndrome suddenly presented with numbness of her right upper limb. Magnetic resonance imaging showed multiple acute infarctions in her left cerebrum, and magnetic resonance angiography (MRA) showed...

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Bibliographic Details
Published in:Internal Medicine 2019/12/15, Vol.58(24), pp.3573-3575
Main Authors: Sakuta, Kenichi, Mukai, Taiji, Suzuki, Kazuhito, Nishiwaki, Kaichi, Yaguchi, Hiroshi
Format: Article
Language:English
Subjects:
Angiography
Blood vessels
Brain - blood supply
Brain - diagnostic imaging
Brain Ischemia - diagnostic imaging
Brain Ischemia - etiology
Case Report
Cerebrum
Endocrine disorders
Female
Humans
Internal medicine
ischemic stroke
Lesions
Magnetic Resonance Angiography
Magnetic resonance imaging
Middle Aged
Neuroimaging
POEMS syndrome
POEMS Syndrome - complications
POEMS Syndrome - drug therapy
Polyneuropathy
Resonance
Skin - pathology
Stroke
Stroke - diagnostic imaging
Stroke - etiology
Vascular diseases
vasculopathy
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Summary:A 48-year-old woman with polyneuropathy, organomegaly, endocrinopathy, M-protein, skin change (POEMS) syndrome suddenly presented with numbness of her right upper limb. Magnetic resonance imaging showed multiple acute infarctions in her left cerebrum, and magnetic resonance angiography (MRA) showed multiple intra-cranial vascular lesions, which contrasted with previously normal MRA results obtained eight months prior to the stroke. After completing successful treatment for POEMS syndrome, there were no recurrent stroke episodes. A six-month follow-up scan showed that although the vascular lesions did not progress, they did not improve much either. POEMS syndrome is associated with the rapid extension of large blood vessels-vasculopathy-resulting in nearly irreversible brain lesions.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.3279-19