Cathepsin S as a target in gastric cancer

Cathepsin S (Cat S) is a protein expressed in some epithelial cells, which appears to be associated with cancer metastasis and recurrence. The abnormal expression of Cat S has been reported to be associated with the progression of certain types of gastrointestinal neoplasms, including gastric cancer...

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Bibliographic Details
Published in:Molecular and clinical oncology 2020-02, Vol.12 (2), p.99-103
Main Authors: da Costa, Adriano Carneiro, Santa-Cruz, Fernando, Mattos, Luiz Alberto Reis, Rêgo Aquino, Maria Améllia, Martins, Camila Ramos, Bandeira Ferraz, Álvaro Antônio, Figueiredo, José Luiz
Format: Article
Language:English
Subjects:
Angiogenesis
Anopheles
Apoptosis
Autophagy
Biological markers
Breast cancer
Cancer
Cancer metastasis
Cancer therapies
Carcinogenesis
Cathepsins
Cell adhesion & migration
Development and progression
Epidermal growth factor
Gastric cancer
Gastrointestinal tumors
Kinases
Liver cancer
Mediation
Medical prognosis
Metastasis
Mortality
Novels
Oncology
Recurrence (Disease)
Review
Stomach cancer
Tumors
Vascular endothelial growth factor
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Summary:Cathepsin S (Cat S) is a protein expressed in some epithelial cells, which appears to be associated with cancer metastasis and recurrence. The abnormal expression of Cat S has been reported to be associated with the progression of certain types of gastrointestinal neoplasms, including gastric cancer (GC). There is a need to identify novel biomarkers and therapeutic targets associated with the growth, invasion and migration of GC cells, in order to develop non-invasive diagnostic and prognostic procedures and design new therapeutic approaches. The aim of the present study was to assess the association between Cat S and oncogenic processes implicated in the development of GC, focusing on the diagnostic and therapeutic potential of this molecule in GC. A search was conducted through the PubMed and Cochrane Central Register of Controlled Trials electronic databases for relevant literature published between 2003 and 2018, using the mesh terms 'cathepsin S' and 'cancer' and 'gastric cancer'.
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2019.1958