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Aedes aegypti insecticide resistance underlies the success (and failure) of Wolbachia population replacement
Mosquitoes that carry Wolbachia endosymbionts may help control the spread of arboviral diseases, such as dengue, Zika and chikungunya. Wolbachia frequencies systematically increase only when the frequency-dependent advantage due to cytoplasmic incompatibility exceeds frequency-independent costs, whi...
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Published in: | Scientific reports 2020-01, Vol.10 (1), p.63, Article 63 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Mosquitoes that carry
Wolbachia
endosymbionts may help control the spread of arboviral diseases, such as dengue, Zika and chikungunya.
Wolbachia
frequencies systematically increase only when the frequency-dependent advantage due to cytoplasmic incompatibility exceeds frequency-independent costs, which may be intrinsic to the
Wolbachia
and/or can be associated with the genetic background into which
Wolbachia
are introduced. Costs depend on field conditions such as the environmental pesticide load. Introduced mosquitoes need adequate protection against insecticides to ensure survival after release. We model how insecticide resistance of transinfected mosquitoes determines the success of local
Wolbachia
introductions and link our theoretical results to field data. Two
Ae
.
aegypti
laboratory strains carrying
Wolbachia
were released in an isolated district of Rio de Janeiro, Brazil:
w
MelBr (susceptible to pyrethroids) and
w
MelRio (resistant to pyrethroids). Our models elucidate why releases of the susceptible strain failed to result in
Wolbachia
establishment, while releases of the resistant strain led to
Wolbachia
transforming the native
Ae
.
aegypti
population. The results highlight the importance of matching insecticide resistance levels in release stocks to those in the target natural populations during
Wolbachia
deployment. |
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ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/s41598-019-56766-4 |