KangFuXin Liquid in the Treatment of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis

Background. Diabetic foot ulcer (DFU) is one of the most common complications of diabetes mellitus, with the wound not healing as expected and healing slowly. Poor control can develop into gangrene and even amputation. Currently, the existing treatments are not satisfactory enough. In China, KangFuX...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2019, Vol.2019 (2019), p.1-10
Main Authors: Que, Hua Fa, Wang, Xuan Yu, Hu, Xiao Jie, Liang, Yue, Li, Yang, Qu, Ke Shen, Chen, Xin
Format: Article
Language:English
Subjects:
Amputation
Analysis
Antibiotics
Bias
Chinese medicine
Clinical trials
Complications
Diabetes
Diabetes mellitus
Diabetes therapy
Diabetic foot
Drug therapy
Evidence, Expert
Feet
Flow velocity
Foot diseases
Gangrene
Health aspects
Insulin
Intervention
Leg ulcers
Meta-analysis
Review
Systematic review
Wound healing
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Summary:Background. Diabetic foot ulcer (DFU) is one of the most common complications of diabetes mellitus, with the wound not healing as expected and healing slowly. Poor control can develop into gangrene and even amputation. Currently, the existing treatments are not satisfactory enough. In China, KangFuXin liquid (KFXL) has been clinically used to treat DFU and has shown good clinical efficacy. In order to provide more reference to clinicians and experts, evidence of efficacy for it needs to be further rigorously evaluated. Methods. Eight electronic databases were searched to identify eligible randomized clinical trials (RCTs) published from construction of the library to April 2019. There is no language or data restriction; 11 trials involving 889 participants met the inclusion criteria. These RCTs compared the total effective rate, cure rate, cure time, and adverse events associated with KFXL. The Cochrane Handbook guidelines were used to assess the risk of bias and to evaluate the methodological quality of eligible studies. The methodological quality of included studies was generally low. Dichotomous and continuous data were presented using risk ratios (RRs) and mean differences (MDs), respectively. Results. Compared with the basic treatment, meta-analyses showed that KFXL combined with basic treatment can improve the total effective rate (RR = 1.38; 95% CI = 1.23–1.54; P
ISSN:1741-427X
1741-4288
DOI:10.1155/2019/3678714