Immune‐mediated adverse reactions to vaccines

Vaccination continues to be the single most important and successful public health intervention, due to its prevention of morbidity and mortality from prevalent infectious diseases. Severe immunologically mediated reactions are rare and less common with the vaccine than the true infection. However,...

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Bibliographic Details
Published in:British journal of clinical pharmacology 2019-12, Vol.85 (12), p.2694-2706
Main Authors: Stone, Cosby A., Rukasin, Christine R.F., Beachkofsky, Thomas M., Phillips, Elizabeth J.
Format: Article
Language:English
Subjects:
adverse drug reactions
allergy
drug allergy
Guillain-Barre Syndrome - chemically induced
Guillain-Barre Syndrome - immunology
Humans
hypersensitivity
Hypersensitivity, Delayed - chemically induced
Hypersensitivity, Delayed - immunology
Hypersensitivity, Immediate - chemically induced
Hypersensitivity, Immediate - immunology
Immunocompromised Host - drug effects
Immunocompromised Host - immunology
Immunoglobulin E - blood
immunology
Review
Reviews
Skin Tests
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
Vaccination - adverse effects
Vaccination - mortality
Vaccine Excipients - adverse effects
vaccines
Vaccines - adverse effects
Vaccines - chemistry
Vaccines - immunology
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Summary:Vaccination continues to be the single most important and successful public health intervention, due to its prevention of morbidity and mortality from prevalent infectious diseases. Severe immunologically mediated reactions are rare and less common with the vaccine than the true infection. However, these events can cause public fearfulness and loss of confidence in the safety of vaccination. In this paper, we perform a systematic literature search and narrative review of immune‐mediated vaccine adverse events and their known and proposed mechanisms, and outline directions for future research. Improving our knowledge base of severe immunologically mediated vaccine reactions and their management drives better vaccine safety and efficacy outcomes.
ISSN:0306-5251
1365-2125
DOI:10.1111/bcp.14112