Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors

Acetylcholinesterase cysteine-targeted insecticides against malaria vector Anopheles gambia and other mosquitos have already been introduced. We have applied the olefin metathesis for the preparation of cysteine-targeted insecticides in high yields. The prepared compounds with either a succinimide o...

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Published in:ACS medicinal chemistry letters 2020-01, Vol.11 (1), p.65-71
Main Authors: Gorecki, Lukas, Andrys, Rudolf, Schmidt, Monika, Kucera, Tomas, Psotka, Miroslav, Svobodova, Barbora, Hrabcova, Veronika, Hepnarova, Vendula, Bzonek, Petr, Jun, Daniel, Kuca, Kamil, Korabecny, Jan, Musilek, Kamil
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Language:English
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Letter
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Summary:Acetylcholinesterase cysteine-targeted insecticides against malaria vector Anopheles gambia and other mosquitos have already been introduced. We have applied the olefin metathesis for the preparation of cysteine-targeted insecticides in high yields. The prepared compounds with either a succinimide or maleimide moiety were evaluated on Anopheles gambiae and human acetylcholinesterase with relatively high irreversible inhibition of both enzymes but poor selectivity. The concept of cysteine binding was not proved by several methods, and poor stability was observed of the chosen most potent/selective compounds in a water/buffer environment. Thus, our findings do not support the proposed concept of cysteine-targeted selective insecticides for the prepared series of succinimide or maleimide compounds.
ISSN:1948-5875
1948-5875
DOI:10.1021/acsmedchemlett.9b00477