Synthesis and applications of theranostic oligonucleotides carrying multiple fluorine atoms

The use of various oligonucleotide (ON) syntheses and post-synthetic strategies for targeted chemical modification enables improving their efficacy as potent modulators of gene expression levels in eukaryotic cells. However, the search still continues for new approaches designed for increasing inter...

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Bibliographic Details
Published in:Theranostics 2020, Vol.10 (3), p.1391-1414
Main Authors: Metelev, Valeriy G, Bogdanov, Jr, Alexei A
Format: Article
Language:English
Subjects:
Acids
Animals
Cell Line
Fluorine
Fluorine - chemistry
Gene expression
Humans
Hydrocarbons
Magnetic Resonance Imaging
Nanoparticles - chemistry
Oligonucleotides - chemistry
Oligonucleotides - pharmacokinetics
Perfluorocarbons
Permeability
Precision Medicine - methods
Review
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Summary:The use of various oligonucleotide (ON) syntheses and post-synthetic strategies for targeted chemical modification enables improving their efficacy as potent modulators of gene expression levels in eukaryotic cells. However, the search still continues for new approaches designed for increasing internalization, lysosomal escape, and tissue specific delivery of ON. In this review we emphasized all aspects related to the synthesis and properties of ON derivatives carrying multifluorinated (MF) groups. These MF groups have unique physico-chemical properties because of their simultaneous hydrophobicity and lipophobicity. Such unusual combination of properties results in the overall modification of ON mode of interaction with the cells and making multi-fluorination highly relevant to the goal of improving potency of ON as components of new therapies. The accumulated evidence so far is pointing to high potential of ON probes, RNAi components and ON imaging beacons carrying single or multiple MF groups for improving the stability, specificity of interaction with biological targets and delivery of ONs and potentially .
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.37936