Expression of miR-551b and its effect on apoptosis in human gastric carcinoma

miR-551b has been reported to be involved in tumorigenesis, cell invasion, and metastasis in gastric cancer but the mechanism remains unclear. In this study, in an attempt to address this question, we examined expression of miR-551b in gastric tumors and adjacent normal tissue. We transfected SGC-79...

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Published in:International journal of clinical and experimental pathology 2018-01, Vol.11 (5), p.2912-2919
Main Authors: Wang, Yanan, Fan, Xiangyu, Xu, Fang, Zhang, Pei, Wei, Yaning, Cheng, Shujie, Zhao, Po
Format: Article
Language:English
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Summary:miR-551b has been reported to be involved in tumorigenesis, cell invasion, and metastasis in gastric cancer but the mechanism remains unclear. In this study, in an attempt to address this question, we examined expression of miR-551b in gastric tumors and adjacent normal tissue. We transfected SGC-7901 gastric cancer cells with miRNA non-sense sequences (NC group), miR-551b mimics (miR-551b mimic group), and miR-551b inhibitors (miR-551b inhibitor group) to investigate the role of miR-551b in autophagic apoptosis. In gastric tissue, our real-time PCR results revealed that expression of miR-551b was significantly downregulated and the relative expression of miR-551b (1.75 ± 0.13) was significantly lower than in normal tissue (2.47 ± 0.38) (
ISSN:1936-2625