Clinicopathological features and prognostic value of mismatch repair protein deficiency in gastric cancer

The microsatellite instability (MSI) tumor is one of the four molecular subtypes in gastric cancer (GC). MSI tumors are sensitive to immune checkpoint blockade therapy. However the prevalence and characteristics of MSI in GCs remains unclear. We aimed to clarify relationships between MSI and clinico...

Full description

Saved in:
Bibliographic Details
Published in:International journal of clinical and experimental pathology 2018-01, Vol.11 (5), p.2579-2587
Main Authors: Zhang, Qiongyan, Wang, Lei, Ni, Shujuan, Tan, Cong, Cai, Xu, Huang, Dan, Sheng, Weiqi
Format: Article
Language:English
Subjects:
Original
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 2587
container_issue 5
container_start_page 2579
container_title International journal of clinical and experimental pathology
container_volume 11
creator Zhang, Qiongyan
Wang, Lei
Ni, Shujuan
Tan, Cong
Cai, Xu
Huang, Dan
Sheng, Weiqi
description The microsatellite instability (MSI) tumor is one of the four molecular subtypes in gastric cancer (GC). MSI tumors are sensitive to immune checkpoint blockade therapy. However the prevalence and characteristics of MSI in GCs remains unclear. We aimed to clarify relationships between MSI and clinicopathological features along with patients' survival rates. Data was collected from a cohort of 567 consecutive GC patients who received radical gastrectomy in Fudan University Shanghai Cancer Center. Expression of four DNA mismatch repair proteins (MMRPs)-MLH1, PSM2, MSH2, MSH6 was assessed using immunohistochemistry staining. Absence of any of the four MMRPs was defined as deficiency mismatch repair (dMMR). Tumors with preserved expression of all MMRPs were considered MMR-proficient (pMMR). Chi-squared test or Fisher's exact probability test was used to detect correlation between MMR status and clinicopathological parameters. Kaplan-Meier method and Log-rank test were used for survival analysis. Fifty-seven cases (57/567, 10.1%) were confirmed as dMMR. The dMMR status was in significant correlation with older age (
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6958290</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2338990861</sourcerecordid><originalsourceid>FETCH-LOGICAL-p196t-5ba73f4f84ef2ededaf2e2f66991ec888c5ecdf975402049887b9b992ec9257b3</originalsourceid><addsrcrecordid>eNpVkM1LxDAQxYsg7vrxL0iOXgpt0qbJRZDFL1jwoucyTSfdSJrUJF3Y_96Kq-jpMbw3v8fMSbYuJeM55bReZecxvhcFL2lVnGUrtjiCNeU6MxtrnFF-grTz1g9GgSUaIc0BIwHXkyn4wfmYjCJ7sDMSr8lo4ghJ7UjACUz4yiQ0jvSojTLo1IEs0wAxhWVNgVMYLrNTDTbi1VEvsreH-9fNU759eXze3G3zqZQ85XUHDdOVFhVqij32sAjVnEtZohJCqBpVr2VTVwUtKilE08lOSopK0rrp2EV2-82d5m7EXqFLAWw7BTNCOLQeTPvfcWbXDn7fclkLKosFcHMEBP8xY0ztcq5Ca8Ghn2NLGRNSFoKXS_T6b9dvyc9_2SdxKnoo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2338990861</pqid></control><display><type>article</type><title>Clinicopathological features and prognostic value of mismatch repair protein deficiency in gastric cancer</title><source>PubMed Central</source><creator>Zhang, Qiongyan ; Wang, Lei ; Ni, Shujuan ; Tan, Cong ; Cai, Xu ; Huang, Dan ; Sheng, Weiqi</creator><creatorcontrib>Zhang, Qiongyan ; Wang, Lei ; Ni, Shujuan ; Tan, Cong ; Cai, Xu ; Huang, Dan ; Sheng, Weiqi</creatorcontrib><description>The microsatellite instability (MSI) tumor is one of the four molecular subtypes in gastric cancer (GC). MSI tumors are sensitive to immune checkpoint blockade therapy. However the prevalence and characteristics of MSI in GCs remains unclear. We aimed to clarify relationships between MSI and clinicopathological features along with patients' survival rates. Data was collected from a cohort of 567 consecutive GC patients who received radical gastrectomy in Fudan University Shanghai Cancer Center. Expression of four DNA mismatch repair proteins (MMRPs)-MLH1, PSM2, MSH2, MSH6 was assessed using immunohistochemistry staining. Absence of any of the four MMRPs was defined as deficiency mismatch repair (dMMR). Tumors with preserved expression of all MMRPs were considered MMR-proficient (pMMR). Chi-squared test or Fisher's exact probability test was used to detect correlation between MMR status and clinicopathological parameters. Kaplan-Meier method and Log-rank test were used for survival analysis. Fifty-seven cases (57/567, 10.1%) were confirmed as dMMR. The dMMR status was in significant correlation with older age ( &lt;0.001), female gender ( =0.016), distal tumor location in stomach ( =0.002), intestinal Lauren classification ( &lt;0.001), less lymph node metastasis ( =0.040), and less nerve invasion ( =0.016). The dMMR tumors often exhibited unique nested, trabecular or solid growth pattern with an expanding margin and many infiltrating lymphocytes. Patients with dMMR phenotype had improved disease-free survival ( =0.024) and overall survival rates ( =0.025) compared to those with pMMR status. Cox regression analysis manifested dMMR status was an independent factor of better prognosis. In summary, GC with dMMR subtype had distinct clinicopathological features.</description><identifier>EISSN: 1936-2625</identifier><identifier>PMID: 31938371</identifier><language>eng</language><publisher>United States: e-Century Publishing Corporation</publisher><subject>Original</subject><ispartof>International journal of clinical and experimental pathology, 2018-01, Vol.11 (5), p.2579-2587</ispartof><rights>IJCEP Copyright © 2018.</rights><rights>IJCEP Copyright © 2018 2018</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958290/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958290/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31938371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Qiongyan</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Ni, Shujuan</creatorcontrib><creatorcontrib>Tan, Cong</creatorcontrib><creatorcontrib>Cai, Xu</creatorcontrib><creatorcontrib>Huang, Dan</creatorcontrib><creatorcontrib>Sheng, Weiqi</creatorcontrib><title>Clinicopathological features and prognostic value of mismatch repair protein deficiency in gastric cancer</title><title>International journal of clinical and experimental pathology</title><addtitle>Int J Clin Exp Pathol</addtitle><description>The microsatellite instability (MSI) tumor is one of the four molecular subtypes in gastric cancer (GC). MSI tumors are sensitive to immune checkpoint blockade therapy. However the prevalence and characteristics of MSI in GCs remains unclear. We aimed to clarify relationships between MSI and clinicopathological features along with patients' survival rates. Data was collected from a cohort of 567 consecutive GC patients who received radical gastrectomy in Fudan University Shanghai Cancer Center. Expression of four DNA mismatch repair proteins (MMRPs)-MLH1, PSM2, MSH2, MSH6 was assessed using immunohistochemistry staining. Absence of any of the four MMRPs was defined as deficiency mismatch repair (dMMR). Tumors with preserved expression of all MMRPs were considered MMR-proficient (pMMR). Chi-squared test or Fisher's exact probability test was used to detect correlation between MMR status and clinicopathological parameters. Kaplan-Meier method and Log-rank test were used for survival analysis. Fifty-seven cases (57/567, 10.1%) were confirmed as dMMR. The dMMR status was in significant correlation with older age ( &lt;0.001), female gender ( =0.016), distal tumor location in stomach ( =0.002), intestinal Lauren classification ( &lt;0.001), less lymph node metastasis ( =0.040), and less nerve invasion ( =0.016). The dMMR tumors often exhibited unique nested, trabecular or solid growth pattern with an expanding margin and many infiltrating lymphocytes. Patients with dMMR phenotype had improved disease-free survival ( =0.024) and overall survival rates ( =0.025) compared to those with pMMR status. Cox regression analysis manifested dMMR status was an independent factor of better prognosis. In summary, GC with dMMR subtype had distinct clinicopathological features.</description><subject>Original</subject><issn>1936-2625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpVkM1LxDAQxYsg7vrxL0iOXgpt0qbJRZDFL1jwoucyTSfdSJrUJF3Y_96Kq-jpMbw3v8fMSbYuJeM55bReZecxvhcFL2lVnGUrtjiCNeU6MxtrnFF-grTz1g9GgSUaIc0BIwHXkyn4wfmYjCJ7sDMSr8lo4ghJ7UjACUz4yiQ0jvSojTLo1IEs0wAxhWVNgVMYLrNTDTbi1VEvsreH-9fNU759eXze3G3zqZQ85XUHDdOVFhVqij32sAjVnEtZohJCqBpVr2VTVwUtKilE08lOSopK0rrp2EV2-82d5m7EXqFLAWw7BTNCOLQeTPvfcWbXDn7fclkLKosFcHMEBP8xY0ztcq5Ca8Ghn2NLGRNSFoKXS_T6b9dvyc9_2SdxKnoo</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Zhang, Qiongyan</creator><creator>Wang, Lei</creator><creator>Ni, Shujuan</creator><creator>Tan, Cong</creator><creator>Cai, Xu</creator><creator>Huang, Dan</creator><creator>Sheng, Weiqi</creator><general>e-Century Publishing Corporation</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180101</creationdate><title>Clinicopathological features and prognostic value of mismatch repair protein deficiency in gastric cancer</title><author>Zhang, Qiongyan ; Wang, Lei ; Ni, Shujuan ; Tan, Cong ; Cai, Xu ; Huang, Dan ; Sheng, Weiqi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p196t-5ba73f4f84ef2ededaf2e2f66991ec888c5ecdf975402049887b9b992ec9257b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Qiongyan</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Ni, Shujuan</creatorcontrib><creatorcontrib>Tan, Cong</creatorcontrib><creatorcontrib>Cai, Xu</creatorcontrib><creatorcontrib>Huang, Dan</creatorcontrib><creatorcontrib>Sheng, Weiqi</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of clinical and experimental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Qiongyan</au><au>Wang, Lei</au><au>Ni, Shujuan</au><au>Tan, Cong</au><au>Cai, Xu</au><au>Huang, Dan</au><au>Sheng, Weiqi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological features and prognostic value of mismatch repair protein deficiency in gastric cancer</atitle><jtitle>International journal of clinical and experimental pathology</jtitle><addtitle>Int J Clin Exp Pathol</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>11</volume><issue>5</issue><spage>2579</spage><epage>2587</epage><pages>2579-2587</pages><eissn>1936-2625</eissn><abstract>The microsatellite instability (MSI) tumor is one of the four molecular subtypes in gastric cancer (GC). MSI tumors are sensitive to immune checkpoint blockade therapy. However the prevalence and characteristics of MSI in GCs remains unclear. We aimed to clarify relationships between MSI and clinicopathological features along with patients' survival rates. Data was collected from a cohort of 567 consecutive GC patients who received radical gastrectomy in Fudan University Shanghai Cancer Center. Expression of four DNA mismatch repair proteins (MMRPs)-MLH1, PSM2, MSH2, MSH6 was assessed using immunohistochemistry staining. Absence of any of the four MMRPs was defined as deficiency mismatch repair (dMMR). Tumors with preserved expression of all MMRPs were considered MMR-proficient (pMMR). Chi-squared test or Fisher's exact probability test was used to detect correlation between MMR status and clinicopathological parameters. Kaplan-Meier method and Log-rank test were used for survival analysis. Fifty-seven cases (57/567, 10.1%) were confirmed as dMMR. The dMMR status was in significant correlation with older age ( &lt;0.001), female gender ( =0.016), distal tumor location in stomach ( =0.002), intestinal Lauren classification ( &lt;0.001), less lymph node metastasis ( =0.040), and less nerve invasion ( =0.016). The dMMR tumors often exhibited unique nested, trabecular or solid growth pattern with an expanding margin and many infiltrating lymphocytes. Patients with dMMR phenotype had improved disease-free survival ( =0.024) and overall survival rates ( =0.025) compared to those with pMMR status. Cox regression analysis manifested dMMR status was an independent factor of better prognosis. In summary, GC with dMMR subtype had distinct clinicopathological features.</abstract><cop>United States</cop><pub>e-Century Publishing Corporation</pub><pmid>31938371</pmid><tpages>9</tpages></addata></record>
fulltext fulltext
identifier EISSN: 1936-2625
ispartof International journal of clinical and experimental pathology, 2018-01, Vol.11 (5), p.2579-2587
issn 1936-2625
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6958290
source PubMed Central
subjects Original
title Clinicopathological features and prognostic value of mismatch repair protein deficiency in gastric cancer
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T02%3A38%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinicopathological%20features%20and%20prognostic%20value%20of%20mismatch%20repair%20protein%20deficiency%20in%20gastric%20cancer&rft.jtitle=International%20journal%20of%20clinical%20and%20experimental%20pathology&rft.au=Zhang,%20Qiongyan&rft.date=2018-01-01&rft.volume=11&rft.issue=5&rft.spage=2579&rft.epage=2587&rft.pages=2579-2587&rft.eissn=1936-2625&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E2338990861%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p196t-5ba73f4f84ef2ededaf2e2f66991ec888c5ecdf975402049887b9b992ec9257b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2338990861&rft_id=info:pmid/31938371&rfr_iscdi=true