Vitamin D Supplementation in Overweight/obese Asian Indian Women with Prediabetes Reduces Glycemic Measures and Truncal Subcutaneous Fat: A 78 Weeks Randomized Placebo-Controlled Trial (PREVENT-WIN Trial)

• Published in: Scientific reports 2020-01, Vol.10 (1), p.220, Article 220
• Main Authors: Bhatt, Surya Prakash, Misra, Anoop, Pandey, Ravindra Mohan, Upadhyay, Ashish Datt, Gulati, Seema, Singh, Namrata
• Format: Article
• Language: English
• Subjects: 692/163/2743/2815; 692/699/2743/2815; Adult; Blood; Blood Glucose - analysis; Body composition; Body weight; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - prevention & control; Dietary Supplements; Etiology; Fasting; Female; Glucose; Glucose tolerance; Glycated Hemoglobin - analysis; Hemoglobin; Humanities and Social Sciences; Humans; India - epidemiology; Intervention; Laboratory testing; Middle Aged; multidisciplinary; Obesity; Obesity - physiopathology; Overweight; Overweight - physiopathology; Prediabetic State - drug therapy; Prediabetic State - epidemiology; Prediabetic State - metabolism; Science; Science (multidisciplinary); Supplements; Vitamin D; Vitamin D - administration & dosage; Vitamin deficiency; Vitamins - administration & dosage; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-019-56904-y

Vitamin D deficiency may contribute to etiology of type 2 diabetes in Asian Indians. The objectives of this study was to evaluate effect of vitamin D supplementation on glycemic profile and body composition in prediabetic and vitamin D deficient overweight/obese Asian Indian women. In this open-label randomized placebo-controlled trial (78 weeks duration), 121 females (aged 20–60 years) with prediabetes and vitamin D deficiency were randomly allocated in intervention (n, 61) and placebo (n, 60) groups. The primary outcome variables were fasting blood glucose (FBG), 2-h blood glucose post OGTT (2-h BG), hemoglobin A1c (HbA1C), and reversal to normoglycemia. In Intention-to-treat analysis, at the end of intervention, we observed significant decrease in FBG [−5.0 (−12.6–2.4), p = 0.04], 2-h blood glucose post OGTT [−11(−49.3–26.9), p = 0.02], hemoglobin A1c [−0.41 (5.89, 6.55), p = 0.05] and increase in 25(OH) D [7.5 (−6.0–20.9), p = 0.002] levels in intervention as compared to the placebo group. Changes in glycemic category based on FBG were as follows; intervention group: normal FBG, 58.6%; impaired fasting glucose (IFG), 39%; and type 2 diabetes mellitus (T2DM), 2.4%; placebo group: normal FBG, 48.8%; IFG, 46.3%; and T2DM, 4.9%. Changes in category of 2-hour glucose post OGTT after intervention were as follows; intervention group: normal glucose tolerance (NGT) 51.2% and prediabetes, 48.8%; placebo group: NGT, 43.9%; prediabetes, 53.7% and T2DM, 2.4%. After intervention, subscapular skinfold (visit I st compared to visit III rd ) and suprailiac skinfold (visit II nd compared to visit III rd ) were significantly lower in intervention group vs . control group. In conclusion, we observed significant reduction in FBG, 2-hour glucose post OGTT, HbA1c, and truncal subcutaneous fat and reversal to normoglycemia in overweight/obese prediabetic vitamin D deficient Asian Indian women after 78 weeks of vitamin D supplementation.