Preparation and pH Controlled Release of Fe3O4/Anthocyanin Magnetic Biocomposites

Anthocyanins are a class of antioxidants extracted from plants, with a variety of biochemical and pharmacological properties. However, the wide and effective applications of anthocyanins have been limited by their relatively low stability and bioavailability. In order to expand the application of an...

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Bibliographic Details
Published in:Polymers 2019-12, Vol.11 (12), p.2077
Main Authors: Jiang, Xizhi, Guan, Qingbao, Feng, Min, Wang, Mengyang, Yan, Nina, Wang, Min, Xu, Lei, Gui, Zhongzheng
Format: Article
Language:English
Subjects:
Adsorption
Anthocyanins
Antioxidants
Bioavailability
Biomedical materials
Composite materials
Controlled release
Crosslinking
Ethanol
Fourier transforms
Infrared analysis
Iron oxides
Nanoparticles
Photon correlation spectroscopy
Polymers
Scanning electron microscopy
Thermal analysis
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Summary:Anthocyanins are a class of antioxidants extracted from plants, with a variety of biochemical and pharmacological properties. However, the wide and effective applications of anthocyanins have been limited by their relatively low stability and bioavailability. In order to expand the application of anthocyanins, Fe3O4/anthocyanin magnetic biocomposite was fabricated for the storage and release of anthocyanin in this work. The magnetic biocomposite of Fe3O4 magnetic nanoparticle-loaded anthocyanin was prepared through physical intermolecular adsorption or covalent cross-linking. Scanning electron microscopy (SEM), Dynamic light scattering (DLS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and thermal analysis were used to characterize the biocomposite. In addition, the anthocyanin releasing experiments were performed. The optimized condition for the Fe3O4/anthocyanin magnetic biocomposite preparation was determined to be at 60 °C for 20 h in weak alkaline solution. The smooth surface of biocomposite from SEM suggested that anthocyanin was coated on the surface of the Fe3O4 particles successfully. The average size of the Fe3O4/anthocyanin magnetic biocomposite was about 222 nm. Under acidic conditions, the magnetic biocomposite solids could be repeatable released anthocyanin, with the same chemical structure as the anthocyanin before compounding. Therefore, anthocyanin can be effectively adsorbed and released by this magnetic biocomposite. Overall, this work shows that Fe3O4/anthocyanin magnetic biocomposite has great potential for future applications as a drug storage and delivery nanoplatform that is adaptable to medical, food and sensing.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym11122077