The Plasticity of Newly Formed B Cells

Newly formed B cells (NF-B cells) that emerge from the bone marrow to the periphery have often been referred to as immature or transitional B cells. However, NF-B cells have several striking characteristics, including a distinct BCR repertoire, high expression of AID, high sensitivity to PAMPs, and...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2019-12, Vol.203 (12), p.3095-3104
Main Authors: Giltiay, Natalia V, Giordano, Daniela, Clark, Edward A
Format: Article
Language:English
Subjects:
Animals
Autoantibodies - immunology
Autoimmunity
Cell Plasticity - physiology
Cytidine Deaminase - metabolism
Humans
Immunoglobulin Class Switching - immunology
Infections - immunology
Lupus Erythematosus, Systemic - immunology
Lymphocyte Activation - immunology
Mice
Precursor Cells, B-Lymphoid - immunology
Precursor Cells, B-Lymphoid - metabolism
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Summary:Newly formed B cells (NF-B cells) that emerge from the bone marrow to the periphery have often been referred to as immature or transitional B cells. However, NF-B cells have several striking characteristics, including a distinct BCR repertoire, high expression of AID, high sensitivity to PAMPs, and the ability to produce cytokines. A number of findings do not support their designation as immature because NF-B cells have the potential to become Ab-producing cells and to undergo class-switch recombination. In this review, we provide a fresh perspective on NF-B cell functions and describe some of the signals driving their activation. We summarize growing evidence supporting a role for NF-B cells in protection against infections and as a potential source of autoantibody-producing cells in autoimmune diseases such as systemic lupus erythematosus.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.1900928