Clozapine-induced late-onset angioedema

Clozapine is an atypical antipsychotic which is generally used as a second line antipsychotic drug in clinical practice due to its side effects. It is known that Clozapine may induce hypersensitivity reaction, angioedema at the beginning of the treatment, late onset angioedema related to clozapine t...

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Bibliographic Details
Published in:Indian journal of psychiatry 2020-01, Vol.62 (1), p.95-96
Main Authors: Gürbüz, Hatice, Seçinti, Dilara, Neze, Handan
Format: Article
Language:English
Subjects:
Angioedema
Angioneurotic edema
Antibiotics
Antipsychotics
Blood
Case Report
Child & adolescent psychiatry
Clozapine
Edema
Hypersensitivity
Psychotropic drugs
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Summary:Clozapine is an atypical antipsychotic which is generally used as a second line antipsychotic drug in clinical practice due to its side effects. It is known that Clozapine may induce hypersensitivity reaction, angioedema at the beginning of the treatment, late onset angioedema related to clozapine treatment is very rare in the literature. In this case report, we present a 19 years old man who was admitted to psychiatry with clozapine induced periorbital edema. He was receiving clozapine 200 mg per day for last two years when he applied to psychiatry. After reducing daily dose of clozapine to 150 mg, his periorbital edema regressed. It should be known that clozapine induced angioedema may develop not only at the beginning of the treatment but also during the treatment and may regress with dose reduction.
ISSN:0019-5545
1998-3794
DOI:10.4103/psychiatry.indianjpsychiatry_379_18