Systematic Elucidation of the Potential Mechanism of Erzhi Pill against Drug-Induced Liver Injury via Network Pharmacology Approach

Objective. The purpose of this work was to investigate the bioactive compounds, core genes, and pharmacological mechanisms and to provide a further research orientation of Erzhi pill (EZP) on drug-induced liver injury (DILI). Methods. At first, we collected information of bioactive compounds of EZP...

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Published in:Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-15
Main Authors: Wang, Jing-wen, Lei, Lu, Zhang, Wei, Wang, Wen-jun, Li, Fei, Mu, Fei, Huang, Shao-jie, Ma, Yang
Format: Article
Language:English
Subjects:
AKT1 protein
Apoptosis
Bioactive compounds
Cell cycle
Chinese medicine
Drugs
Encyclopedias
Epidermal growth factor receptors
FDA approval
Gelatinase B
Gene expression
Genomes
Herbal medicine
Insulin-like growth factor I
Lipid metabolism
Liver
Medicine, Chinese
Metabolism
Orientation behavior
Pharmacology
Physiological aspects
Proteins
Traditional Chinese medicine
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Summary:Objective. The purpose of this work was to investigate the bioactive compounds, core genes, and pharmacological mechanisms and to provide a further research orientation of Erzhi pill (EZP) on drug-induced liver injury (DILI). Methods. At first, we collected information of bioactive compounds of EZP from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and previous studies. And then, the targets related to bioactive compounds and DILI were obtained from 4 public databases. At last, Cytoscape was used to establish a visual network. Moreover, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses and network analysis were performed to investigate potential mechanism of EZP against DILI. Results. A total of 23 bioactive compounds and 89 major proteins of EZP were screened out as potential players against DILI. Association for bioactive compounds, core targets, and related pathways was analyzed, implying that core targets related to these pathways are ALB, AKT1, MAPK1, EGFR, SRC, MAPK8, IGF1, CASP3, HSP90AA1, and MMP9, and potential mechanisms of EZP acting on DILI are closely related to negative regulation of apoptosis process, improvement of lipid metabolism, and positive regulation of liver regeneration process. Conclusion. This study demonstrated the multicompound, multitarget, and multichannel characteristics of EZP, which provided a novel approach for further research the mechanism of EZP in the treatment of DILI.
ISSN:1741-427X
1741-4288
DOI:10.1155/2020/6219432