Isolation of food-derived bacteria inducing interleukin-22 in B cells

Recently, we found a novel function of the lactic acid bacterium Tetragenococcus halophilus derived from miso, a fermented soy paste, that induces interleukin (IL)-22 production in B cells preferentially. IL-22 plays a critical role in barrier functions in the gut and skin. We further screened other...

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Bibliographic Details
Published in:Bioscience of Microbiota, Food and Health Food and Health, 2020, Vol.39(1), pp.1-9
Main Authors: KUMAZAWA, Toshihiko, KOTAKE, Kunihiko, NISHIMURA, Atsuhisa, ASAI, Noriyuki, UGAJIN, Tsukasa, YOKOZEKI, Hiroo, ADACHI, Takahiro
Format: Article
Language:English
Subjects:
B cell
Bacteria
CD69 antigen
CD86 antigen
Cell activation
Cytokines
Fermented food
food
IL-22
Interleukin 22
Intestinal microflora
Lactic acid
Lymphocytes
Lymphocytes B
Lymphocytes T
Microbiota
miso
Robustness
Skin
skin barrier
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Summary:Recently, we found a novel function of the lactic acid bacterium Tetragenococcus halophilus derived from miso, a fermented soy paste, that induces interleukin (IL)-22 production in B cells preferentially. IL-22 plays a critical role in barrier functions in the gut and skin. We further screened other bacteria species, namely, Enterococcus, Lactobacillus, Lactococcus, Leuconostoc, Weissella, Pediococcus, and Bacillus, in addition to Tetragenococcus and found that some of them possessed robust IL-22-inducible function in B cells in vitro. This process resulted in the augmented expression of activation markers CD86 and CD69 on B and T cells, respectively. However, these observations were not correlated with IL-22 production. We isolated Bacillus coagulans sc-09 from miso and determined it to be the best strain to induce robust IL-22 production in B cells. Furthermore, feeding B. coagulans sc-09 to mice augmented the barrier function of the skin regardless of gut microbiota.
ISSN:2186-3342
2186-6953
2186-3342
DOI:10.12938/bmfh.19-012