Increased blood pressure variability during the subacute phase of ischemic stroke is associated with poor functional outcomes at 3 months

• Published in: Scientific reports 2020-01, Vol.10 (1), p.811, Article 811
• Main Authors: Naito, Hiroyuki, Hosomi, Naohisa, Kuzume, Daisuke, Nezu, Tomohisa, Aoki, Shiro, Morimoto, Yuko, Kinboshi, Masato, Yoshida, Takeshi, Shiga, Yuji, Kinoshita, Naoto, Ueno, Hiroki, Noma, Kensuke, Yamasaki, Masahiro, Maruyama, Hirofumi
• Format: Article
• Language: English
• Subjects: 692/699/75/243; 692/699/75/593/1370/534; Aged; Aged, 80 and over; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Brain Ischemia - physiopathology; Brain Ischemia - therapy; Coefficient of variation; Female; Humanities and Social Sciences; Humans; Hypertension; Ischemia; Male; Middle Aged; multidisciplinary; Multivariate Analysis; Retrospective Studies; Science; Science (multidisciplinary); Standard deviation; Stroke; Stroke - physiopathology; Stroke - therapy; Treatment Outcome; Variability
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-57661-z

Thus far, it is well known that increased blood pressure variability may exacerbate stroke outcomes. Blood pressure in the acute phase would be influenced by both reactive hypertension to stroke and intrinsic blood pressure reactivity. Thus, we aimed to evaluate the association between blood pressure variability and outcomes at 3 months using ambulatory blood pressure monitoring in ischemic stroke patients in the subacute phase after reactive hypertension subsided. We retrospectively examined 626 consecutive patients with acute ischemic stroke who underwent 24-hour ambulatory blood pressure monitoring during the subacute phase of stroke (median, 9 days from onset). The variability in blood pressure was evaluated by assessing the standard deviation and coefficient of variation of systolic and diastolic blood pressure. The primary outcome was functional status at 3 months. A poor outcome was defined as a modified Rankin scale score of 3 or more and a good outcome as 2 or less. We assessed the functional outcome at 3 months in 497 patients (79.4%). The mean systolic and diastolic blood pressure levels were not associated with functional outcome. The multivariable analysis revealed that increases in the standard deviations of systolic and diastolic blood pressure, coefficient of variation of diastolic blood pressure, and morning blood pressure surge were associated with poor outcome. Blood pressure variability during the subacute phase of ischemic stroke can be a useful prognostic indicator of poor functional outcome at 3 months in patients with acute ischemic stroke.