What Kind of Probucol Affects Normalizing Male Birth?

[See article vol.27 : 25-37] High-density lipoprotein (HDL) cholesterol (HDL-C), induced by activation of the ATP-binding cassette transporter A1 (ABCA1), has been associated with anti-atherosclerosis. Probucol originally gained attention as an antioxidant compound through a rubber manufacturing pro...

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Bibliographic Details
Published in:Journal of Atherosclerosis and Thrombosis 2020/01/01, Vol.27(1), pp.4-5
Main Authors: Komatsu, Tomohiro, Uehara, Yoshinari
Format: Article
Language:English
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Summary:[See article vol.27 : 25-37] High-density lipoprotein (HDL) cholesterol (HDL-C), induced by activation of the ATP-binding cassette transporter A1 (ABCA1), has been associated with anti-atherosclerosis. Probucol originally gained attention as an antioxidant compound through a rubber manufacturing process. Although it significantly reduces the HDL-C level in blood by strongly inhibiting ABCA1, several anti-atherosclerotic effects have been reported. Some if these effects are contrary to prediction. At Present, probucol is a controversial drug, with extremely difficult-to-recognize overall efficacy. Infertility in both scavenger receptor BI (SR-BI)-deficient mice with high HDL-C levels and ABCA1-deficent mice with very low HDL-C levels were previously reported.
ISSN:1340-3478
1880-3873
DOI:10.5551/jat.ED115