Developing and aging: A tale of two stages

Compared to high‐functioning autism, the low‐functioning autism is usually compounded by presence of intellectual disability and psychological dysfunctions, of which the brain networks tend to be more delicate and disorganized. [...]treatment options for individuals with low‐functioning autism are q...

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Bibliographic Details
Published in:CNS neuroscience & therapeutics 2020-02, Vol.26 (2), p.281-282
Main Author: Lu, Hanna
Format: Article
Language:English
Subjects:
Aging
Autism
Cognitive ability
Conflicts of interest
Cortex (motor)
Cortex (parietal)
Functional magnetic resonance imaging
Intellectual disabilities
Letter to the Editor
Letters to the Editor
Neurodevelopmental disorders
Neuroimaging
Pediatrics
Prefrontal cortex
Researchers
Scalp
Structure-function relationships
Supplementary motor area
Transcranial magnetic stimulation
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Summary:Compared to high‐functioning autism, the low‐functioning autism is usually compounded by presence of intellectual disability and psychological dysfunctions, of which the brain networks tend to be more delicate and disorganized. [...]treatment options for individuals with low‐functioning autism are quite limited. Based on the knowledge we learned from aging brain, the dynamic changes within a short period, such as half a year, can be recognized from functional and structural MRI, which highlights the need to combine individual MRI data; (b) Scalp‐to‐cortex distance (SCD): As highlighted in the NIBS guidelines, SCD, as a key parameter of neuroimaging and brain stimulation, could significantly influence the focality and strength of electric field ; (c) Heterogeneity: The large variability in the therapeutic effect of NIBS studies may be caused by the inter‐individual differences of neurophysiological, cognitive, and morphometric features. Of particular relevance of TMS, neurodevelopmental disorders have been associated with the abnormal activity within the cortical hubs of specific brain network, such as dorsolateral prefrontal cortex (DLPFC), posterior parietal cortex (PPC), and supplementary motor area (SMA).
ISSN:1755-5930
1755-5949
DOI:10.1111/cns.13264