Multiple Timescales Account for Adaptive Responses across Sensory Cortices

• Published in: The Journal of neuroscience 2019-12, Vol.39 (50), p.10019-10033
• Main Authors: Latimer, Kenneth W, Barbera, Dylan, Sokoletsky, Michael, Awwad, Bshara, Katz, Yonatan, Nelken, Israel, Lampl, Ilan, Fairhall, Adriene L, Priebe, Nicholas J
• Format: Article
• Language: English
• Subjects: Adaptation; Adaptive systems; Attenuation; Environmental effects; Membrane potential; Sensory integration; Sensory stimulation; Sensory systems; Sound filters
• ISSN: 0270-6474; 1529-2401
• DOI: 10.1523/JNEUROSCI.1642-19.2019

Sensory systems encounter remarkably diverse stimuli in the external environment. Natural stimuli exhibit timescales and amplitudes of variation that span a wide range. Mechanisms of adaptation, a ubiquitous feature of sensory systems, allow for the accommodation of this range of scales. Are there common rules of adaptation across different sensory modalities? We measured the membrane potential responses of individual neurons in the visual, somatosensory, and auditory cortices of male and female mice to discrete, punctate stimuli delivered at a wide range of fixed and nonfixed frequencies. We find that the adaptive profile of the response is largely preserved across these three areas, exhibiting attenuation and responses to the cessation of stimulation, which are signatures of response to changes in stimulus statistics. We demonstrate that these adaptive responses can emerge from a simple model based on the integration of fixed filters operating over multiple time scales. Our recent sensations affect our current expectations and perceptions of the environment. Neural correlates of this process exist throughout the brain and are loosely termed adaptation. Adaptive processes have been described across sensory cortices, but direct comparisons of these processes have not been possible because paradigms have been tailored specifically for each modality. We developed a common stimulus set that was used to characterize adaptation in somatosensory, visual, and auditory cortex. We describe here the similarities and differences in adaptation across these cortical areas and demonstrate that adaptive responses may emerge from a set of static filters that operate over a broad range of timescales.