The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer

The microbiome is able to modulate immune responses, alter the physiology of the human organism, and increase the risk of viral infections and development of diseases such as cancer. In this review, we address changes in the cervical microbiota as potential biomarkers to identify the risk of cervica...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-12, Vol.21 (1), p.222
Main Authors: Curty, Gislaine, de Carvalho, Pedro S, Soares, Marcelo A
Format: Article
Language:English
Subjects:
Bacteria
Biomarkers
Biomarkers, Tumor - analysis
Breast cancer
Carcinogens
Cervical cancer
Cervical Intraepithelial Neoplasia - diagnosis
Cervical Intraepithelial Neoplasia - etiology
Cervical Intraepithelial Neoplasia - microbiology
Cervix
Cloning
Endometrial cancer
Female
Genitalia, Female - microbiology
Human papillomavirus
Humans
Immune response
Infections
Invasiveness
Lung cancer
Microbiomes
Microbiota
Microorganisms
Ovarian cancer
Physiology
Probiotics
Prostate
Review
Signatures
Transplantation
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - etiology
Uterine Cervical Neoplasms - microbiology
Vagina
Viral infections
Womens health
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Summary:The microbiome is able to modulate immune responses, alter the physiology of the human organism, and increase the risk of viral infections and development of diseases such as cancer. In this review, we address changes in the cervical microbiota as potential biomarkers to identify the risk of cervical intraepithelial neoplasia (CIN) development and invasive cervical cancer in the context of human papillomavirus (HPV) infection. Current approaches for clinical diagnostics and the manipulation of microbiota with the use of probiotics and through microbiota transplantation are also discussed.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21010222