Emerging Role of Non-Coding RNAs in Esophageal Squamous Cell Carcinoma

Esophageal squamous cell carcinoma (ESCC) is a highly prevalent tumor and is associated with ethnicity, genetics, and dietary intake. Non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) have been reported as functional regulatory molecules i...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-12, Vol.21 (1), p.258
Main Authors: Feng, Qingqing, Zhang, Hongli, Yao, Denglin, Chen, Wei-Dong, Wang, Yan-Dong
Format: Article
Language:English
Subjects:
Apoptosis
Biomarkers
Cancer therapies
Cell adhesion & migration
Cell cycle
Cell growth
Cell Proliferation
Cervical cancer
Chemotherapy
Coding
Dietary intake
Disease Progression
Esophageal cancer
Esophageal Neoplasms - genetics
Esophageal Neoplasms - metabolism
Esophageal Squamous Cell Carcinoma - genetics
Esophageal Squamous Cell Carcinoma - metabolism
Esophagus
Gene expression
Gene Expression Regulation, Neoplastic
Humans
Metastasis
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Neoplasm Metastasis
Non-coding RNA
Pathogenesis
Physiology
Regulation
Review
RNA, Circular - genetics
RNA, Circular - metabolism
RNA, Long Noncoding - metabolism
RNA, Untranslated - genetics
RNA, Untranslated - metabolism
Roles
Squamous cell carcinoma
Tumors
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Summary:Esophageal squamous cell carcinoma (ESCC) is a highly prevalent tumor and is associated with ethnicity, genetics, and dietary intake. Non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) have been reported as functional regulatory molecules involved in the development of many human cancers, including ESCC. Recently, several ncRNAs have been detected as oncogenes or tumor suppressors in ESCC progression. These ncRNAs influence the expression of specific genes or their associated signaling pathways. Moreover, interactions of ncRNAs are evident in ESCC, as miRNAs regulate the expression of lncRNAs, and further, lncRNAs and circRNAs function as miRNA sponges to compete with the endogenous RNAs. Here, we discuss and summarize the findings of recent investigations into the role of ncRNAs (miRNAs, lncRNAs, and circRNAs) in the development and progression of ESCC and how their interactions regulate ESCC development.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21010258