Kv12.1 channels are not sensitive to GqPCR-triggered activation of phospholipase Cβ

K v 12.1 K + channels are expressed in several brain areas, but no physiological function could be attributed to these subunits so far. As genetically-modified animal models are not available, identification of native K v 12.1 currents must rely on characterization of distinct channel properties. Re...

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Bibliographic Details
Published in:Channels (Austin, Tex.) Tex.), 2018-08, Vol.12 (1), p.228-239
Main Authors: Dierich, Marlen, Leitner, Michael G
Format: Article
Language:English
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Brief Report
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Summary:K v 12.1 K + channels are expressed in several brain areas, but no physiological function could be attributed to these subunits so far. As genetically-modified animal models are not available, identification of native K v 12.1 currents must rely on characterization of distinct channel properties. Recently, it was shown in Xenopus laevis oocytes that K v 12.1 channels were modulated by membrane PI(4,5)P 2 . However, it is not known whether these channels are also sensitive to physiologically-relevant PI(4,5)P 2 dynamics. We thus studied whether K v 12.1 channels were modulated by activation of phospholipase C β (PLCβ) and found that they were insensitive to receptor-triggered depletion of PI(4,5)P 2 . Thus, K v 12.1 channels add to the growing list of K + channels that are insensitive to PLCβ signaling, although modulated by PI(4,5)P 2 in Xenopus laevis oocytes.
ISSN:1933-6950
1933-6969
DOI:10.1080/19336950.2018.1475783