Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis

We applied terahertz (THz)-pulsed spectroscopy to study ex vivo the refractive index and absorption coefficient of human brain gliomas featuring different grades, as well as perifocal regions containing both intact and edematous tissues. Glioma samples from 26 patients were considered and analyzed a...

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Bibliographic Details
Published in:Journal of biomedical optics 2019-02, Vol.24 (2), p.1-5
Main Authors: Gavdush, Arseniy A, Chernomyrdin, Nikita V, Malakhov, Kirill M, Beshplav, Sheyh-Islyam T, Dolganova, Irina N, Kosyrkova, Alexandra V, Nikitin, Pavel V, Musina, Guzel R, Katyba, Gleb M, Reshetov, Igor V, Cherkasova, Olga P, Komandin, Gennady A, Karasik, Valery E, Potapov, Alexander A, Tuchin, Valery V, Zaytsev, Kirill I
Format: Article
Language:English
Subjects:
Absorptivity
Adolescent
Adult
Aged
Brain
Brain - diagnostic imaging
Brain cancer
Brain Neoplasms - diagnostic imaging
Diagnosis
Edema
Edema - diagnostic imaging
Embedding
Female
Gelatin
Gelatin - chemistry
Glioma
Glioma - diagnostic imaging
Histological Techniques
Histology
Humans
Male
Medical prognosis
Middle Aged
Refractivity
Refractometry
Sensing
Spectroscopy
Spectrum analysis
Terahertz Spectroscopy - methods
Tissues
Tumors
Young Adult
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Summary:We applied terahertz (THz)-pulsed spectroscopy to study ex vivo the refractive index and absorption coefficient of human brain gliomas featuring different grades, as well as perifocal regions containing both intact and edematous tissues. Glioma samples from 26 patients were considered and analyzed according to further histological examination. In order to fix tissues for the THz measurements, we applied gelatin embedding, which allows for sustaining their THz response unaltered, as compared to that of the freshly excised tissues. We observed a statistical difference between the THz optical constants of intact tissues and gliomas of grades I to IV, while the response of edema was similar to that of tumor. The results of this paper justify a potential of THz technology in the intraoperative label-free diagnosis of human brain gliomas for ensuring the gross-total resection.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.24.2.027001