Intravenous Immunoglobulin in the Management of Lupus Erythematosus Panniculitis

Lupus erythematosus panniculitis (LEP) is a rare variant of cutaneous lupus erythematosus (CLE). It is characterized by the presence of a chronic inflammatory process involving the deep dermis and subcutaneous tissues. It commonly presents as deep indurated nodules or sharply demarcated plaques. Ant...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2020-01, Vol.12 (1), p.e6790
Main Authors: AlQadri, Nada G, AlNooh, Bayan, AlTewerki, Malak M, Almotairi, Ahmad, Alajlan, Saad
Format: Article
Language:English
Subjects:
Alopecia
Atrophy
Baldness
Blood & organ donations
Case reports
Dermatitis
Dermatology
Drug dosages
Immunoglobulins
Internal Medicine
Lupus
Pain
Rheumatology
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Summary:Lupus erythematosus panniculitis (LEP) is a rare variant of cutaneous lupus erythematosus (CLE). It is characterized by the presence of a chronic inflammatory process involving the deep dermis and subcutaneous tissues. It commonly presents as deep indurated nodules or sharply demarcated plaques. Antimalarial medications are considered first-line therapy for most cases of LEP while systemic corticosteroids are saved for more resistant lesions. Intravenous immunoglobulin (IVIG) is made up of concentrated polyclonal immunoglobulin G (IgG) fractionated from the blood of healthy blood donors. Nowadays, it is used for the treatment of numerous autoimmune and systemic inflammatory diseases. In this case, we report the case of a female with multiple LEP and discoid lupus erythematosus (DLE) lesions refractory to multiple standard therapy modalities that responded dramatically to IVIG.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.6790