Spatial frequency domain imaging using an analytical model for separation of surface and volume scattering

A method to correct for surface scattering in spatial frequency domain imaging (SFDI) is presented. The use of a modified analytical solution of the radiative transfer equation allows calculation of the reflectance and the phase of a rough semi-infinite geometry so that both spatial frequency domain...

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Bibliographic Details
Published in:Journal of biomedical optics 2019-07, Vol.24 (7), p.071604-071604
Main Authors: Nothelfer, Steffen, Bergmann, Florian, Liemert, André, Reitzle, Dominik, Kienle, Alwin
Format: Article
Language:English
Subjects:
Exact solutions
Frequency dependence
Frequency domain analysis
Inverse problems
Light
Optical Imaging - methods
Optical properties
Phantoms, Imaging
Polarizers
Radiative transfer
Reflectance
Scattering
Scattering, Radiation
Special Section on Spatial Frequency Domain Imaging
Surface Properties
Surface roughness
Systematic errors
Topography
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Summary:A method to correct for surface scattering in spatial frequency domain imaging (SFDI) is presented. The use of a modified analytical solution of the radiative transfer equation allows calculation of the reflectance and the phase of a rough semi-infinite geometry so that both spatial frequency domain reflectance and phase can be applied for precise retrieval of the bulk optical properties and the surface scattering. For validation of the method, phantoms with different surface roughness were produced. Contrarily, with the modified theory, it was possible to dramatically reduce systematic errors due to surface scattering. The evaluation of these measurements with the state-of-the-art theory and measuring modality, i.e., using crossed linear polarizers, reveals large errors in the determined optical properties, depending on the surface roughness, of up to ≈100  %  . These results were confirmed with SFDI measurements on a phantom that has a structured rough surface.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.24.7.071604